中国药物警戒 ›› 2012, Vol. 9 ›› Issue (9): 550-552.

• 药械安全性研究 • 上一篇    下一篇

160例克林霉素注射剂致肾毒性病例分析

江腊梅1, 齐向荣2   

  1. 1 济南市药品不良反应监测中心,山东 济南250001；
    2 济南市第二人民医院,山东 济南250031
  • 收稿日期:2011-12-08 出版日期:2012-09-10 发布日期:2015-08-07
  • 作者简介:江腊梅,女,主任药师,药品不良反应监测与评价。

Analysis of 160 Cases of Kidney Toxicity Caused by Clindamycin Injection

JIANG La-Mei1, Qi Xiang-Rong2   

  1. 1 Jinan Adverse Drug and Device Reaction Monitoring Center, Shandong Jinan 250001, China;
    2 the Second people's Hospital of Jinan, Shandong Jinan 250031, China
  • Received:2011-12-08 Online:2012-09-10 Published:2015-08-07

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摘要： 目的分析克林霉素注射剂在临床应用中致血尿及肾衰竭的因素,为临床合理用药提供参考。方法检索2005~2011年6月国内医药期刊报道的克林霉素注射剂致肾毒性病例,综合分析克林霉素注射剂的临床用药次数、用量、血药浓度、联合用药及有关物质等。结果160例患者中有86例在用药后20min~2h内出现急性肾衰及血尿（占53.75%）,研究认为高浓度用药、滴速快、联合用药及有关物质是导致肾毒性的重要因素。结论更加注重克林霉素的合理使用,规范临床使用的范围和剂量,完善药品说明书,切实提高质量标准。

关键词: 克林霉素注射剂, 肾衰竭, 血尿, 肾毒性

Abstract: Objective To analyze the reasons of hematuria and renal failure in clinical applications of clindamycin injection, to provide references for clinical rational drug use. Methods According to literature retrieval of domestic medical journals from 2005 to June 2011 about the renal toxicity cases induced by Clindamycin injection, to analyze the frequency, dosage, blood drug concentration, combination and related substances of clindamycin injection in clinical medication. Results Acute renal failure and hematuria occurred in 86 cases, accounting for 53.75% of 160 cases. We think that the high concentration of medication, fast dropping speed, combined use of drugs and related substances are the main factors for kidney toxicity. Conclusion Pay more attention to the rational use of Clindamycin. standardize the range and dose in clinical use, perfect the insert sheet and improve the quality specification.

Key words: Clindamycin injection, renal failure, hematuria, kidney toxicity