中国药物警戒 ›› 2021, Vol. 18 ›› Issue (4): 384-387.
DOI: 10.19803/j.1672-8629.2021.04.20

• 安全与合理用药 • 上一篇    下一篇

再次暴露“乙胺吡嗪利福异烟片”致急性肾衰竭1例分析

胡叶敏1, 刘芳2   

  1. 1泸州市妇幼保健院 泸州市第二人民医院 药剂科,四川 泸州 646000;
    2四川大学华西医院肾脏内科,四川 成都 610041
  • 收稿日期:2019-11-28 出版日期:2021-04-15 发布日期:2021-04-23
  • 作者简介:胡叶敏,女,硕士,主管药师,临床药学。

Acute Renal Failure Induced by Repeated Exposure to Ethambutol Hydrochloride, Pyrazinamide, Rifampicin and Isoniazid Tablets

HU Yemin1, LIU Fang2   

  1. 1Department of Pharmacy, Luzhou Maternal and Child Health Care Hospital (Luzhou Second People's Hospital), Luzhou Sichuan 646000, China;
    2Department of Nephrology, West China Hospital of Sichuan University, Chengdu Sichuan 610041, China
  • Received:2019-11-28 Online:2021-04-15 Published:2021-04-23

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摘要： 目的 分析1例55岁女性患者使用乙胺吡嗪利福异烟片(Ⅱ)出现急性肾衰竭不良反应的可能药物及其可能发生机制,总结国内外有关研究进展以供借鉴。方法 临床药师通过查阅分析国内外有关文献,结合患者病情分析,明确导致患者出现不良反应的可能抗结核药物。结果 引起患者出现急性肾衰竭不良反应的抗结核药物可能为间歇服用的“利福平”。结论 使用乙胺吡嗪利福异烟片前,须明确病史病情及适应证,规范用药,尽量避免间歇服用。临床药师参与临床治疗能促进用药合理化,更加保证患者用药安全。

关键词: 药物性急性肾衰竭, 乙胺吡嗪利福异烟片, 利福平, 抗结核药

Abstract: Objective To analyze the causes of adverse reactions of acute renal failure in a 55-year-old female patient treated with ethambutol hydrochloride, pyrazinamide, rifampicin and isoniazid tablets(Ⅱ), and to summarize the experience and lessons learned at home and abroad. Methods By consulting the related literature and based on the patient's condition, clinical pharmacists identified the possible anti-tuberculosis drug that had induced acute renal failure in the patient. Results The adverse reactions of the patient with acute renal failure might have been due to the intermittent use of rifampicin. Conclusion Prior to treatment with ethambutol hydrochloride, pyrazinamide, rifampicin and isoniazid tablets, the medical history and indications of the patient should be clarified. Medication should be standardized and the intermittent use should be avoided as far as possible The participation of a clinical pharmacist in clinical treatment can help make medication more appropriate and ensure the safety of medication.

Key words: drug-induced acute renal failure, ethambutol hydrochloride, pyrazinamide, rifampicin and isoniazid tablets, rifampin, antituberculosis drugs

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