[1] PASTORIZA DLS, ÁLVAREZ J, VéGVáRI Á, et al. Relationship between HMF intake and SMF formation in vivo: an animal and human study[J]. Molecular Nutrition & Food Research, 2017, 61(3): 1600773. [2] LIN N, LIU TT, LIN L, et al.Comparison of in vivo immunomodulatory effects of 5-hydroxymethylfurfural and 5, 5'-oxydimethylenebis (2-furfural)[J]. Regulatory Toxicology and Pharmacology, 2016, 81: 500-511. [3] LIN L, LIN N, LING YH, et al.Acute toxicity and cytotoxicity of 5-hydroxymethylfurfural[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2018, 15(4): 205-209. [4] MONIEN BH, FRANK H, SEIDEL A.et al.Conversion of the common food constituent 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo[J]. Chemical Research in Toxicology, 2009, 22(6): 1123-1128. [5] JIANG HY, GAO SS, HU G, et al.Innovation in drug toxicology: application of mass spectrometry imaging technology[J]. Toxicology, 2021, 464: 153000. [6] JIANG HY, ZHANG YX, LIU ZG, et al.Advanced applications of mass spectrometry imaging technology in quality control and safety assessments of traditional Chinese medicines[J]. Journal of Ethnopharmacology, 2021, 284: 114760. [7] HE JM, TANG F, LUO ZG, et al.Air flow assisted ionization for remote sampling of ambient mass spectrometry and its application[J]. Rapid Communications in Mass Spectrometry, 2011, 25(7): 843-850. [8] WANG ZH, HE BS, LIU Y, et al.In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging[J]. Acta pharmaceutica Sinica B, 2020, 10(6): 1083-1093. [9] NILSSON A, FORNGREN B, BJURSTRÖM S, et al. In situ mass spectrometry imaging and ex vivo characterization of renal crystalline deposits induced in multiple preclinical drug toxicology studies[J]. PloS One, 2012, 7(10): e47353. [10] HUANG W, LIU CX, XIE LJ, et al.Integrated network pharm-acology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide[J]. Toxicol Res (Camb), 2019, 8(6): 850-861. [11] OYARZÚN C, GARRIDO W, ALARCóN S, et al. Adenosine contribution to normal renal physiology and chronic kidney disease[J]. Molecular Aspects of Medicine, 2017, 55: 75-89. [12] RUAN LY, ZHAO WL, LUO BZX, et al.NMR-based metabolomics approach to evaluate the toxicological risks of Tibetan medicine‘Ershiwuwei Shanhu’pill in rats[J]. Journal of Ethnopharmacology, 2022, 282: 114629. [13] KANG H M, AHN S H, CHOI P, et al.Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development[J]. Nat Med, 2015, 21(1): 37-46. [14] DUANN P, LIN PH.Mitochondria damage and kidney disease[J]. Adv Exp Med Biol, 2017, 982: 529-551. [15] CUI Y,LI HS,SONG NN, et al.Metabolomics study of the effects of aristolochic acidⅠon fatty acidβoxidation, glucose metabolism and TCA cycle in mouse liver[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2019, 16(8): 449-466. [16] XIA JF, LIANG QL, ZHONG HF, et al.Effect of Tangshen prescription on purine and pyrimidine metabolism in diabetic nephropathy[J]. Chinese Patent Drug(中成药), 2011, 33(1): 13-17. [17] QIU JF, CHENG JD, XIE YC, et al.1,4-Dioxane exposure induces kidney damage in mice by perturbing specific renal metabolic pathways: an integrated omics insight into the underlying mechanisms[J]. Chemosphere, 2019, 228: 149-158. [18] ZHANG S, LI C, FENG TT, et al.A metabolic profiling study of realgar-induced acute kidney injury in mice[J]. Front Pharmacol, 2021, 12: 706249. |