中国药物警戒 ›› 2012, Vol. 9 ›› Issue (7): 427-430.

• 药械安全性研究 • 上一篇    下一篇

维生素K1注射液不良反应146例文献分析

黄元1, 王春婷2*, 田月洁1   

  1. 1 山东省药品不良反应监测中心,山东 济南 250013；
    2 国家食品药品监督管理局药品评价中心,北京 100045
  • 收稿日期:2011-05-22 出版日期:2012-07-10 发布日期:2015-08-07
  • 通讯作者: 王春婷,女,副主任药师,药品不良反应监测与评价。
  • 作者简介:黄元,女,主管药师,药品不良反应监测

Literature Analysis of 146 Cases of Adverse Drug Reactions Induced by Vitamin-K1 Injection

HUANG Yuan1, WANG Chun-ting2, TIAN Yue-jie1   

  1. 1 Shandong Center for ADR Monitoring,Jinan 250013, China;
    2 Center for Drug Reevaluation SFDA Beijing 100045, China
  • Received:2011-05-22 Online:2012-07-10 Published:2015-08-07

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摘要： 目的探讨维生素K1注射液致不良反应的一般规律特点,为临床合理用药提供参考。方法检索中国期刊全文数据库,对2011年12月31日之前国内公开发表文献中,有关维生素K1注射液致不良反应146例个案报道进行回顾性分析。结果维生素K1注射液发生的不良反应可能与药物因素、患者自身因素、临床使用因素相关。结论临床应合理使用维生素K1注射液,重视药物不良反应的临床监测,确保用药安全。

关键词: 维生素K1注射液, 不良反应, 文献分析

Abstract: Objective We probe into the status, characteristics and influencing factors of ADR cases induced by vitamin-K1 injection, for providing a reference for clinical treatment. Methods Date were collected from domestic published literatures from "China Journal Full-text Database" before December 31, 2011 and 146 case reports of adverse drug reactions induced by vitamin-K1 injection were analyzed retrospectively. Results Adverse drug reactions induced by vitamin-K1 injection may be related to pharmaceutical factors, patients' factors and clinical using factors. Conclusion Vitamin-K1 injection should be used reasonably and attach importance to monitoring of clinical to ensure the safety of medication.

Key words: vitamin-K1 injection, adverse drug Reactions, literature analysis