药物与车祸

中国药物警戒 ›› 2012, Vol. 9 ›› Issue (3): 173-177.

药物与车祸

周密妹，郭梅，尹丽芳

武汉科技大学附属天佑医院临床药学室，湖北武汉 430064

收稿日期:2011-07-01 出版日期:2012-03-10 发布日期:2015-08-10
作者简介:周密妹，女，主任药师，临床药学。

Medicines and Vehicle Crashes

ZHOU Mi-mei, GUO Mei, YIN Li-fang

Affiliated Hospital of Wuhan University of Science and Technology, Hubei Wuhan 430064, China

Received:2011-07-01 Online:2012-03-10 Published:2015-08-10

摘要/Abstract

摘要： 能作用于中枢神经系统、血糖、血压、视力以及对驾驶功能有妨碍的药物为潜在驾驶者伤害药物，此类药物包括中枢神经系统药物、抗组胺药、抗高血压药、抗糖尿病药、镇痛药等，其主要不良表现为镇静、嗜睡、眩晕、低血压、低血糖、视力模糊、动作失调等。有必要对这类药害事件提高警惕并采取有效防范措施。

关键词: 药物, 驾驶者伤害, 车祸

Abstract: Medicines that have known effects on the central nervous system, blood glucose levels, blood pressure, vision, or otherwise have the potential to interfere with driving skills have been termed "potentially driver-impairing" (PDI). These mcdicines include CNS depressants, antihistamine, antihypertensive drugs, hypoglycemics, pain relievers etc. PDI effects include sedation, drowsiness, dizziness, hypotension, hypoglycemia, blurred vision and loss of coordination. It is important to increase awareness among health care providers and drivers regarding the potential driver impairing effects of pharmaceutical use.

Key words: medicines, potentially driver-impairing, vehicle crashes

周密妹，郭梅，尹丽芳. 药物与车祸[J]. 中国药物警戒, 2012, 9(3): 173-177.

ZHOU Mi-mei, GUO Mei, YIN Li-fang. Medicines and Vehicle Crashes[J]. Chinese Journal of Pharmacovigilance, 2012, 9(3): 173-177.

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参考文献

[1] Leroy A, Morse MM, for US DOT/NHTSA. Exploratory study of?the relationship between multiple medications and vehicle?crashes. Was-hington,DC:U.S.DOT/NHTSA;2008[EB/OL].http://www.nhtsa.gov/DOT/NHTSA/810858.pdf. Accessed December 4, 2010.
[2] Couper FJ, Logan BK for US DOT/NHTSA.Drugs and human performance fact sheets.Washington,DC:2004[EB/OL].http://www.nhtsa.dot.gov/people/injury/drugs_web.pdf.Accessed December 4, 2010.
[3] Thomson Healthcare eds. Donnatal Extentabs prescribing information. In: Physicians' Desk Reference[M]. 2009. 63d ed. New York, NY: Thomson Reuters, 2009:2507.
[4] Stefanacci RG, Cavallaro E, Beers MH, et al. Developing explicit positive beers criteria for preferred central nervous system medications in older adults[J]. Consult Pharm. 2009;24:601-610.
[5] Hebert C, Delaney JA, Hemmelgarn B,et al. Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designs[J]. Pharmacoepidemiol Drug Saf. 2007;16:845-849.
[6] Meskali M, Berthelon C, Marie S, et al. Residual effects of hypnotic drugs in aging drivers submitted to simulated accident scenarios: an exploratory study[J]. Psychopharmacology.2009; 207(3):461-467.
[7] Ramaekers J. Antidepressants and driver impairment: empirical evidence from a standard on-the-road test[J]. J Clin Psychiatry. 2003;64:20-29.
[8] Fluoxetine hydrochloride. US FDA, CDER website. Rockaway, NJ: Eli Lilly and Company[EB/OL]. May 4, 2009. http://www.accessdata.fda.gov/drugsatfda_docs.Accessed December 14, 2009.
[9] Trazodone hydrochloride. Princeton, NJ: Bristol-Myers Squibb[EB/OL]. February 2009. http://packageinserts.bms.com/pi. Accessed December 14, 2009.
[10] Venlafaxine hydrochloride. US FDA, CDER website. Philadelphia, Pa: Wyeth Pharmaceuticals[EB/OL].November, 2008. http://www.wyeth.com/content. Accessed December 10, 2010.

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