常用药品不良反应信号检测方法介绍

中国药物警戒 ›› 2011, Vol. 8 ›› Issue (5): 294-298.

常用药品不良反应信号检测方法介绍

任经天^1,2, 王胜锋¹, 侯永芳², 杜晓曦², 李立明¹

1. 北京大学医学部公共卫生学院流行病与卫生统计学系,北京 100191;
2. 国家食品药品监督管理局药品评价中心,北京 100045

收稿日期:2015-08-27 修回日期:2015-08-27 出版日期:2011-05-10 发布日期:2015-08-27
通讯作者: 李立明,男,教授,博士生导师,流行病学。E-mail:lmlee@vip.163.com*杜晓曦,女,研究员,药品评价与药品不良反应监测。E-mail:duxiaoxi@cdr.gov.cn
作者简介:任经天,男,副研究员,在读博士研究生,药品再评价与药品风险管理。

Common Signal Detection Methods of Adverse Drug Reaction

REN Jing-tian^1,2, WANG Sheng-feng¹, HOU Yong-fang², DU Xiao-xi², LI Li-ming¹

1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China;
2. Center for Drug Reevaluation,SFDA, Beijing 100045, China

Received:2015-08-27 Revised:2015-08-27 Online:2011-05-10 Published:2015-08-27

摘要/Abstract

摘要： 系统介绍了报告比值比、比例报告比、信息成分法、（多项）伽玛泊松分布缩减法4种常用药品不良反应信号检测方法及其工作原理,为在我国开展信号检测工作提供了参考。

关键词: 药品不良反应, 信号检测, 数据挖掘

Abstract: This paper aims to give some references for adverse drug reaction(ADR) signal detection in China, by summarizing the common used signal detection Methods and rationale, such as the Reporting Odd Ratio, Proportional Reporting Ratio, Information Component and Gamma-Poisson Shrinker.

Key words: adverse drug reaction, signal detection, data mining

中图分类号:

R954

任经天, 王胜锋, 侯永芳, 杜晓曦, 李立明. 常用药品不良反应信号检测方法介绍[J]. 中国药物警戒, 2011, 8(5): 294-298.

REN Jing-tian, WANG Sheng-feng, HOU Yong-fang, DU Xiao-xi, LI Li-ming. Common Signal Detection Methods of Adverse Drug Reaction[J]. Chinese Journal of Pharmacovigilance, 2011, 8(5): 294-298.

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（因版面有限,部分参考文献省略,如有需要,请联系编辑部）

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