中国药物警戒 ›› 2010, Vol. 7 ›› Issue (9): 517-519.

• 基础研究 • 上一篇    下一篇

黄芩对硫酸镉及丝裂霉素C诱发小鼠遗传损伤的抑制作用

武广恒1,孙健2,朱珠1,温得中1,陆培信1,章宏1   

  1. 1.吉林大学白求恩医学院,吉林长春 130021；
    2.中国中医科学院医学实验中心,北京 100700
  • 收稿日期:2010-07-10 修回日期:2016-03-09 出版日期:2010-09-08 发布日期:2016-03-09
  • 通讯作者: 章宏,男,博士,中药毒理及生理研究。E-mail：hzhang@jlu.edu.cn
  • 作者简介:武广恒,男,医学硕士,肿瘤基因与遗传毒理。
  • 基金资助:
    吉林省卫生厅科研课题资助项目（基金编号：2009ZC048）

Inhibitory Effect of Radix Seutellariae on Genetic Damage Induced by CdSO4 and MMC in Mice

WU Guang-heng1, SUN Jian2 ,ZHU Zhu1, WEN De-zhong1, LU Pei-xin1 ,ZHANG Hong1   

  1. 1.Norman Bethune College of Medicine Jilin University, Jilin Changchun 130021, China;
    2.Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2010-07-10 Revised:2016-03-09 Online:2010-09-08 Published:2016-03-09

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摘要： 目的 探讨黄芩对硫酸镉及丝裂霉素C（Mitomycin C,MMC）诱发小鼠遗传损伤的抑制作用。方法采用活体小鼠骨髓嗜多染红细胞（PCE）微核试验（Micronucleus test, MNT）,计算出含微核的嗜多染红细胞的千分率,进行统计学分析。结果黄芩可使硫酸镉及丝裂霉素C 诱发的小鼠骨髓细胞微核（MN）率明显降低,差异具有显著性（ P＜0.01）。CdS04同时加黄芩各剂量组之间微核率差异无显著性（ P>0.05）。结论本实验剂量与条件下黄芩对遗传损伤具有保护作用。

关键词: 黄芩, 微核试验, 抗诱变

Abstract: Objective To study the inhibitory effect of Radix seutellariae on genetic damage induced by CdSO4 and MMC in mice. Methods The micronucleus test of mouse bone marrow cell(MNT) was used, to detect the micronucleus rate in mouse bone marrow cell, and to analysis the micronucleus rates by the statistical compution. Results The frequency of micronucleus in mouse bone marrow induced by CdSO4 and MMC in mice was reduced significantly, showed significant difference(P <0.01). There is no significant difference in there groups of Radix Seutellariae and CdSO4 at the same time( P>0.05). Conclusion Radix Seutellariae has the effect of antimutation under the experimental conditions,and it may be an antimutagen.

Key words: Radix Seutellariae, micronucleus test, antimutation

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