中国药物警戒 ›› 2025, Vol. 22 ›› Issue (2): 224-226.
DOI: 10.19803/j.1672-8629.20240453

• 安全与合理用药 • 上一篇    下一篇

葶苈降血脂胶囊致急性药物性肝损伤1例分析

胡亚萍1,2, 张爱武2,*   

  1. 1内蒙古医科大学药学院,内蒙古 呼和浩特 010110;
    2内蒙古医科大学附属医院药学部,内蒙古 呼和浩特 010050
  • 收稿日期:2024-07-02 出版日期:2025-02-17 发布日期:2025-02-17
  • 通讯作者: *张爱武,女,硕士,主任药师,药品不良反应监测。E-mail: nm_xiaowu@sina.com
  • 基金资助:
    内蒙古自治区自然科学基金资助项目（2018MS08075)

One Case of Acute Drug-Induced Liver Injury Caused by Tingli Jiangxuezhi Capsules

HU Yaping1,2, ZHANG Aiwu2,*   

  1. 1College of Pharmacy, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110, China;
    2Department of Pharmacy, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot Inner Mongolia 010050, China
  • Received:2024-07-02 Online:2025-02-17 Published:2025-02-17

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摘要： 目的 探讨葶苈降血脂胶囊中成分致肝损伤的情况,为临床安全合理用药提供参考。方法 分析1例葶苈降血脂胶囊致肝损伤病例,讨论肝损伤与药物成分间的相关性,并对中国知网、万方数据及维普网建库至2024年6月20日的相关报道检索分析。结果 入院前,葶苈降血脂胶囊为患者单独用药,入院后根据综合评定,急性药物性肝损伤与葶苈降血脂胶囊可能有关,但文献并未检测到葶苈降血脂胶囊致肝损伤的报道,其组方中的大黄、黄芩、木香均可引起肝损伤。结论 含大黄、黄芩、木香类成分可能致肝损伤,医生和药师应关注相关药物,警惕肝损伤的发生。

关键词: 葶苈降血脂, 胶囊, 药物性肝损伤, 大黄, 黄芩, 木香, 药品不良反应

Abstract: Objective To identify the components of Tingli Jiangxuezhi capsules that may cause liver injury so as to provide a reference for safe and rational drug use. Methods One case of liver injury caused by Tingli Jiangxuezhi capsules was analyzed and the correlation between liver injury and components of this drug was studied based on related reports from CNKI, Wanfang, and VIP database that were published from inception to June 20, 2024. Results Before admission to the hospital, the patient was treated with Tingli Jiangxuezhi capsules alone, so these capsules were considered to have caused acute drug-induced liver injury after admission despite the lack of related literature. Rhei radix et rhizome, Scutellariae radix and Aucklandiae radix contained in these capsules could all cause liver injury. Conclusion Rhei radix et rhizome, Scutellariae radix and Aucklandiae radix may lead to liver injury, so clinicians and pharmacists should be alert to the occurrence of such adverse reactions.

Key words: Tingli Jiangxuezhi, Capsules, Drug-induced Liver Injury, Rhei radix et rhizoma, Scutellariae radix, Aucklandiae radix, Adverse Drug Reaction

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