中国药物警戒 ›› 2024, Vol. 21 ›› Issue (11): 1306-1308.
DOI: 10.19803/j.1672-8629.20240492

• 安全与合理用药 • 上一篇    下一篇

注射用头孢曲松钠致儿童免疫性溶血性贫血2例分析

丁邑强1, 吕志英2, 刘沧海3, 温琴琴1, 方小平4,*   

  1. 1赣南医科大学附属兴国医院药剂科,江西 兴国 342400;
    2赣南医科大学附属兴国医院输血科,江西 兴国 342400;
    3赣南医科大学附属兴国医院小儿重症医学科,江西 兴国 342400;
    4赣南医科大学附属兴国医院儿科,江西 兴国 342400
  • 收稿日期:2024-07-19 出版日期:2024-11-15 发布日期:2024-11-20
  • 通讯作者: *方小平,男,本科,副主任医师,儿科。E-mail：839877972@qq.com
  • 作者简介:丁邑强,男,硕士,主管药师,临床药学。
  • 基金资助:
    赣州市卫生健康委员会科研计划项目（GZWJW-202402389）

Two Cases of Ceftriaxone Sodium for Injection Induced Immune Hemolytic Anemia in Children

DING Yiqiang1, LYU Zhiying2, LIU Canghai3, WEN Qinqin1, FANG Xiaoping4,*   

  1. 1Department of Pharmacy, Xingguo Hospital Affiliated to Gannan Medical University, Xingguo Jiangxi 342400, China;
    2Department of Blood Transfusion, Xingguo Hospital Affiliated to Gannan Medical University, Xingguo Jiangxi 342400, China;
    3Department of Pediatric Intensive Care, Xingguo Hospital Affiliated to Gannan Medical University, Xingguo Jiangxi 342400, China;
    4Department of Pediatrics, Xingguo Hospital Affiliated to Gannan Medical University, Xingguo Jiangxi 342400, China
  • Received:2024-07-19 Online:2024-11-15 Published:2024-11-20

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摘要： 目的 探讨头孢曲松致儿童免疫性溶血性贫血的临床特征、发生机制及临床救治。方法 结合文献分析2例注射用头孢曲松钠致儿童免疫性溶血性贫血不良反应的发生机制和相关性。结果 经关联性分析,2例患儿溶血性贫血均为头孢曲松钠所致,均予立即停药,经输血、糖皮质激素治疗后痊愈出院。结论 临床实践中应重视头孢曲松致免疫性溶血性贫血不良反应发生风险,快速识别及适当的免疫学诊断和治疗有助于患者转归。

关键词: 头孢曲松, 免疫性溶血性贫血, 腹痛, 过敏性休克, 药品不良反应, 抗头孢曲松抗体, 血清学检测, 儿童

Abstract: Objective To explore the clinical characteristics and mechanism of adverse drug reactions caused by ceftriaxone in children with immune hemolytic anemia. Methods Two cases of ceftriaxone sodium induced adverse reactions in children with immune hemolytic anemia and the correlations with adverse reactions were analyzed. Results Correlation analysis showed that both cases of hemolytic anemia were caused by ceftriaxone sodium, which was immediately discontinued and the patients were discharged after blood transfusion and glucocorticoid treatment. Conclusion Clinicians should pay attention to the risk of adverse reactions of ceftriaxone-induced immune hemolytic anemia in clinical practice. Rapid identification and appropriate immunological diagnosis and treatment can facilitate the prognosis of patients.

Key words: Ceftriaxone, Immune Hemolytic Anemia, Abdominal Pain, Anaphylactic Shock, Adverse Drug Reaction, Anti-Ceftriaxone Antibody, Serological Test, Children

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