中国药物警戒 ›› 2024, Vol. 21 ›› Issue (7): 816-818.
DOI: 10.19803/j.1672-8629.20240336

• 安全与合理用药 • 上一篇    下一篇

复方聚乙二醇电解质散致患儿过敏样反应2例分析

赵杰1, 高明娥1, 常虹2, 范惠霞1,*   

  1. 1山西省儿童医院药剂科,山西 太原 030013;
    2内蒙古科技大学包头医学院药学院,内蒙古 包头 014040
  • 收稿日期:2024-05-21 出版日期:2024-07-15 发布日期:2024-07-31
  • 通讯作者: * 范惠霞,女,主任药师·硕导,医院药学管理与临床药学。
  • 作者简介:赵杰,女,硕士,主任药师,儿科临床药学。
  • 基金资助:
    国家自然科学基金资助项目（82060784）; 山西省儿童医院山西省妇幼保健院院内科研基金（201964）

Two cases of allergic reactions in children caused by compound polyethylene glycol electrolyte powder

ZHAO Jie1, GAO Ming'e1, CHANG Hong2, FAN Huixia1,*   

  1. 1Department of Pharmacy, Shanxi Provincial Children′s Hospital, Taiyuan Shanxi 030013, China;
    2Department of Pharmacy, Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou Inner Mongolia 014040, China
  • Received:2024-05-21 Online:2024-07-15 Published:2024-07-31

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摘要： 目的 探讨复方聚乙二醇电解质散引起过敏样症状的不良反应,为研究复方聚乙二醇电解质散引起过敏的机制提供参考。方法 对复方聚乙二醇电解质散同时导致同父同母姐弟2例患儿过敏样反应病例进行分析,检索同类文献病例,提出用药建议。结果 2例患儿服用复方聚乙二醇电解质散后同时出现过敏样症状,停用该药,给予抗过敏治疗后症状逐渐消失,分析其因果关系,同时查阅国内外相关文献和病例报告,提示2例患儿出现该不良反应与复方聚乙二醇电解质散很可能相关。结论 这2例复方聚乙二醇电解质散剂过敏反应呈家族聚集性,可能与特定基因位点相关,需进一步研究其与基因分子生物学的关联。提示肠镜操作前服用复方聚乙二醇散剂进行肠道清洁时有引起过敏反应风险,需告知患者尽量避免自行服用,如出现任何不适,应立即停药及时就医。

关键词: 复方聚乙二醇电解质散, 聚乙二醇, 药品不良反应, 过敏样症状, 儿童

Abstract: Objective To explore such adverse reactions as anaphylactic symptoms caused by polyethylene glycol electrolyte powder, and to provide reference for the study of the mechanism underlying allergies caused by polyethylene glycol electrolyte powder. Methods Two cases of allergic reactions in children of the same father and mother caused by polyethylene glycol electrolyte powder were analyzed. Tips for medication were given by searching the literature for similar cases. Results Two children developed allergic symptoms after taking polyethylene glycol electrolyte powder. Symptoms gradually disappeared after discontinuing the drug and giving anti-allergy treatment. Analysis of the causes and review of related literature showed that the adverse reaction in these two children were likely related to polyethylene glycol electrolyte powder. Conclusion Allergic reactions caused by compound polyethylene glycol electrolyte powder reported in this paper tend to run in families, which may be associated with specific gene loci, so the association with gene molecular biology needs to be investigated. There is a risk of allergic reactions when cotrimoxazole polyethylene glycol powder is used for intestinal cleansing prior to colonoscopy operations. Patients need to be reminded to avoid self-administration and to discontinue medication and seek immediate medical attention in case of discomfort.

Key words: polyethylene glycol electrolyte powder, polyethylene glycols, adverse drug reactions, allergy-like symptoms, children

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