热重和差示扫描量热分析技术在药物分析中的应用进展

doi:10.19803/j.1672-8629.20230286

摘要/Abstract

摘要： 目的探讨热重分析（TGA）和差示扫描量热分析（DSC）在药物分析中的应用,为药品质量控制奠定基础。方法通过文献综述着重报道了这2种技术方法在水分含量分析、热稳定性研究、熔点测量、纯度分析、晶型分析等药物研究中的多方面应用研究情况。结果与结论 热重和差示扫描量热分析技术在药物的水分、熔点、纯度、晶型以及稳定性等相关分析中发挥重要作用,满足药品检验检测工作的更高分析需求。

关键词: 热重分析, 差示扫描量热分析, 水分含量, 热稳定性, 熔点, 纯度, 晶型, 安全性

Abstract: Objective To explore the application of thermogravimetric analysis (TGA) and Differential scanning calorimetry (DSC) in drug analysis to lay the foundation for pharmaceutical quality control. Methods a short overview of the applicative research on the water content, thermal stability, melting-point, purity, polymorphism and others in recent years, had been reported. The future development prospect was also discussed. Results and Conclusion TGA and DSC played an important role in the analysis of moisture, melting point, purity, crystallinity and stability of drugs to meet the higher analytical demands of pharmaceutical inspection and testing. It was looking forward to providing methods and ideas for the further research on drug quality and safety.

Key words: thermogravimetric analysis, differential scanning calorimetry, water content, thermal stability, melting-point, purity, polymorphism, safety

中图分类号:

R917

刘毅, 覃玲, 郭贤辉, 陈华, 裴宇盛. 热重和差示扫描量热分析技术在药物分析中的应用进展[J]. 中国药物警戒, 2024, 21(3): 283-289.

LIU Yi, QIN Ling, GUO Xianhui, CHEN Hua, PEI Yusheng. Applications of TGA and DSC in pharmaceutical analysis[J]. Chinese Journal of Pharmacovigilance, 2024, 21(3): 283-289.

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