中国药物警戒 ›› 2023, Vol. 20 ›› Issue (1): 46-51.
DOI: 10.19803/j.1672-8629.20220303

• 基于感染共性作用机制研究专栏 • 上一篇    下一篇

金振口服液对流感病毒H1N1/FM1株和副流感病毒感染致小鼠肺炎的药理作用

张敬升, 高双荣Δ, 庞博, 包蕾, 孙静, 陈梦苹, 徐英莉, 曹姗, 郭姗姗, 赵荣华*, 崔晓兰#   

  1. 中国中医科学院中药研究所,北京 100700
  • 收稿日期:2022-06-06 发布日期:2023-01-19
  • 通讯作者: *赵荣华,女,博士,副研究员,中药药效作用机制研究。E-mail：zhaoronghua203@163.com
    #为共同通信作者。
  • 作者简介:张敬升,男,在读博士,中药抗感染机制研究。
    Δ为并列第一作者。
  • 基金资助:
    国家重点研发计划（2021YFC1712903）; 中国中医科学院科技创新工程（C12021A04606）

Pharmacological effects of Jinzhen oral liquid against viral pneumonia in mice infected with influenza H1N1/FM1 and parainfluenza virus

ZHANG Jingsheng, GAO ShuangrongΔ, PANG Bo, BAO Lei, SUN Jing, CHEN Mengping, XU Yingli, CAO Shan, GUO Shanshan, ZHAO Ronghua*, CUI Xiaolan#   

  1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2022-06-06 Published:2023-01-19

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摘要： 目的 考察金振口服液对流感病毒H1N1/FM1和副流感病毒感染所致的小鼠肺炎药理作用,为金振口服液的临床应用提供一定的参考。方法 采用流感病毒H1N1/FM1和副流感病毒滴鼻感染小鼠造模,考察金振口服液高、中、低剂量组（生药8 、4 、2 g·kg-1·d-1）对小鼠的肺指数、肺组织病理变化和死亡保护作用,并设西药磷酸奥司他韦颗粒、利巴韦林颗粒和中成药小儿热速清口服液作为阳性对照药。结果 金振口服液3个剂量组均可不同程度的降低小鼠肺指数、减轻肺组织病理损伤,并对小鼠具有死亡保护作用。结论 金振口服液对流感病毒H1N1/FM1和副流感病毒感染所致的肺炎小鼠具有治疗作用。

关键词: 金振口服液, 流感病毒H1N1/FM1, 副流感病毒, 肺指数, 肺组织, 磷酸奥司他韦颗粒, 利巴韦林颗粒, 小儿热速清口服液

Abstract: Objective To evaluate the effect of Jinzhen oral liquid (JOL) on a mouse model of pneumonia induced by influenza ( H1N1) FM1 strain and parainfluenza virus in order to provide reference for clinical applications. Methods Mice were randomly divided into the normal group, model group, JOL high-dose group ( 8 g· kg-1·d-1), JOL medium-dose group ( 4 g·kg-1·d-1 ), and JOL low-dose group ( 2 g·kg-1·d-1 ). Mice were infected via intranasal infection with influenza H1N1/FM1 or parainfluenza virus. Oseltamivir phosphate granules, ribavirin granules and Resuqing oral liquid were used as positive control drugs. Four days after the infection,the lung indexes,inhibition rate, pathological changes were observed．In the death protection experiment,the death rate within 14 days was analyzed．Results Compared with the model group, treatment with JOL could lower the lung indexes, alleviate pathological changes of the lung,and reduce mortality of mice. Conclusion JOL can effectively protect the mouse model from pneumonia induced by influenza H1N1/FM1 or parainfluenza virus.

Key words: Jinzhen oral liquid, influenza H1N1/FM1, parainfluenza virus, the lung index, lung tissue, oseltamivir phosphate granule, ribavirin granule, Resuqing oral liquid

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