中国药物警戒 ›› 2023, Vol. 20 ›› Issue (2): 213-214.
DOI: 10.19803/j.1672-8629.20210849

• 安全与合理用药 • 上一篇    下一篇

伤风停胶囊致急性药物性肝损伤1例分析

李晓娟1, 张爱武1*, 魏颖2   

  1. 1内蒙古医科大学附属医院药剂部,内蒙古 呼和浩特 010050;
    2内蒙古医科大学附属医院临床医学研究中心,内蒙古 呼和浩特 010050
  • 收稿日期:2021-09-07 出版日期:2023-02-15 发布日期:2023-02-17
  • 通讯作者: *张爱武,女,硕士,主任药师,药品不良反应监测。Email: nm_xiaowu@sina.com
  • 作者简介:李晓娟,女,硕士,主管药师,临床药学及药品不良反应监测。
  • 基金资助:
    内蒙古自治区自然科学基金资助项目(2021BS08003); 内蒙古医科大学科技百万工程联合项目（YKD2020KJBW(LH)032）

Analysis of one case of acute drug-induced liver injury caused by Shangfengting capsules

LI Xiaojuan1, ZHANG Aiwu1*, WEI Ying2   

  1. 1Department of Pharmacy, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot Inner Mongolia 010050, China;
    2Department of Clinical Medical Research Center, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot Inner Mongolia 010050, China
  • Received:2021-09-07 Online:2023-02-15 Published:2023-02-17

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摘要： 目的 探讨伤风停胶囊致肝损伤的成分,为临床合理用药提供参考。方法 对1例伤风停胶囊致肝损伤的病例进行报道,分析肝损伤与其主要成分间的相关性;检索中国知网、万方数据、维普网建库至 2021年7月19日相关报道进行文献分析。结果 未检索到伤风停胶囊致肝损伤的相关报道,但其组方中的麻黄成分可引起肝细胞型肝损伤,目前机制不明确。结论 含麻黄类成分可能导致肝损伤,临床医生和药师应密切关注,合理用药,减少和避免肝损伤的发生。

关键词: 伤风停胶囊, 药物性肝损伤, 麻黄, 药品不良反应

Abstract: Objective To identify the components of Shangfengting capsules that may cause liver injury so as to provide reference for clinical rational drug use. Methods One case of liver injury caused by Shangfengting capsules was reported and the correlation between liver injury and the main components of this drug was analyzed. CNKI, Wanfang and VIP databases were searched for related literature that was published between inception and July 19, 2021. Results There were no related reports about liver injury caused by Tantanting capsules, but the ephedra in the formula could cause hepatocellular liver injury, and the mechanism was not clear. Conclusion Ephedra may lead to liver injury, so clinicians and pharmacists should manage to ensure the rational use of drugs to reduce and prevent liver injury.

Key words: Shangfengting capsules, drug induced liver injury, ephedra, adverse drug reaction

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