彝族药蜘蛛香的研究进展及质量标志物的预测分析

doi:10.19803/j.1672-8629.20210520

中国药物警戒 ›› 2023, Vol. 20 ›› Issue (3): 348-352.
DOI: 10.19803/j.1672-8629.20210520

彝族药蜘蛛香的研究进展及质量标志物的预测分析

蔡于罗¹, 果佳慧¹, 王鑫国^1,2,3, 田义龙^1,2,3, 王梦^1,2,3, 牛丽颖^1,2,3#, 李军山^1,2,3,4,*

¹河北中医学院,河北石家庄 050091;
²河北省中药配方颗粒技术创新中心,河北石家庄 050091;
³河北省中药材品质评价与标准化工程研究中心,河北石家庄 050091;
⁴神威药业集团有限公司,河北石家庄 051430

收稿日期:2021-05-20 出版日期:2023-03-15 发布日期:2023-03-17
通讯作者: ^* 李军山,男,本科,正高级工程师,药物工艺及质量标准。 E-mail: swljs@sina.com;^#为共同通信作者。
作者简介:蔡于罗,女,在读硕士,中药分析及药效物质基础。
基金资助:
中央引导地方科技发展资金项目（206Z2501G）; 河北省重点研发计划（20372502D）; 河北省自然科学基金资助项目（H2019423050）

Research progress in Yi medicine Valeriana jatamans and predictive analysis of related quality markers

CAI Yuluo¹, GUO Jiahui¹, Wang Xinguo^1,2,3, TIAN Yilong^1,2,3, WANG Meng^1,2,3, NIU Liying^1,2,3#, LI Junshan^1,2,3,4,*

¹Hebei University of Chinese Medicine, Shijiazhuang Hebei 050091, China;
²Hebei TCM Formula Granule Innovation Center, Shijiazhuang Hebei 050091, China;
³Hebei TCM Quality Evaluation & Standardization Engineering Research Center, Shijiazhuang Hebei 050091, China;
⁴Shineway Pharmaceutical Group Ltd., Shijiazhuang Hebei 051430, China

Received:2021-05-20 Online:2023-03-15 Published:2023-03-17

摘要/Abstract

摘要： 彝族药蜘蛛香（Valeriana jatamansi Jones）中含有多种化学成分,主要为环烯醚萜类、挥发油类、木脂素类和黄酮类。据现代药学研究表明,蜘蛛香有多种药理作用,如中枢抑制作用、抗菌和抗病毒作用、细胞毒性和抗肿瘤作用等。本文基于中药质量标志物的概念,从蜘蛛香化学成分特有性、传统药效、传统药性、化学成分可测性等几个方面,对蜘蛛香的中药质量标志物成分进行预测分析,以期为蜘蛛香的质量控制和合理应用提供新思路。

关键词: 蜘蛛香, 环烯醚萜, 挥发油, 药理作用, 质量控制, 质量标志物

Abstract: The Yi medicine Valeriana jatamansi contains many chemical components, such as iridoids, volatile oils, lignans and flavonoids. According to modern pharmaceutical research, Valeriana jatamansi delivers a range of pharmacological effects, such as central inhibition, antibacterial and antiviral effects, cytotoxicity and anti-tumor effect. Based on the concept of Q-markers, this article predicted and analyzed the Q-marker components of Valeriana jatamansi in terms of specificity, traditional medicinal effects, traditional medicinal properties, and measurability of chemical constituents in the hopes of providing reference for quality control and rational use of Valeriana jatamansi.

Key words: Valeriana jatamansi, iridoids, volatile oils, pharmacological effects, quality control, quality marker

中图分类号:

R972
R969.3

蔡于罗, 果佳慧, 王鑫国, 田义龙, 王梦, 牛丽颖, 李军山. 彝族药蜘蛛香的研究进展及质量标志物的预测分析[J]. 中国药物警戒, 2023, 20(3): 348-352.

CAI Yuluo, GUO Jiahui, Wang Xinguo, TIAN Yilong, WANG Meng, NIU Liying, LI Junshan. Research progress in Yi medicine Valeriana jatamans and predictive analysis of related quality markers[J]. Chinese Journal of Pharmacovigilance, 2023, 20(3): 348-352.

参考文献

[1] Chinese Pharmacopoeia Commission.Pharmacopoeia of the People’s Republic of China: Volume Ⅰ(中华人民共和国药典一部)[M]. Beijing: China Medical Science and Technology Press, 2020.
[2] YANG X, GUO JY, LI QY, et al.Study on mechanism of Valerianae Jatamansi Rhizoma et Radix[J]. China Journal of Chinese Materia Medica(中国中药杂志) , 2020, 20(12): 1-13.
[3] THIES PW.Die Konstitution der valepetriate mitteilung ǔber die wirkstoffe des Baldrians[J]. Tetrahedron, 1968, 24(1): 313-347.
[4] THIES PW.Active component of valeriana species[J]. Tetrahedron Letters, 1970, 11(28): 2471.
[5] LIU H, WU J, LIU D, et al.Iridoids from Valeriana jatamansi and their related anti-influenza virus activity[J]. Chinese Herbal Medicine(中草药) , 2020, 51(11): 2886-2894.
[6] HU YQ, ZHANG RS.Study on the chemical constituents and pharmacological effects of the medicinal plant Valeriana jatamansi[J]. Chinese Journal of modern drug application(中国现代药物应用) , 2009, 3(24): 194-197.
[7] HU XN, ZHOU X, LI M, et al.Study on the volatile oil of Valeriana jatamansi with different extraction methods[J]. Chinese Journal of Analysis Laboratory(分析试验室) , 2008, 27(1): 186-189.
[8] ZUO CY, YAN ZY, Progress in Research on Valerenic Acid-a Key Maker Compound of Valeriana[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2010, 16(14): 225-228.
[9] HENDRIKS H, BOS R, WOERDENBAG HJ.Central nervous depressant activity of valerenic acid in the mouse[J]. Planta Medic, 1985, 51(1): 28-31.
[10] WANG HL, WAN X, YAN XL, et al.GC-MS comparative analysis of SFE-CO2 extract of Valeriana jatamansi and volatile oil obtained from steam distillation[J]. China Journal of Chinese Materia Medica(中国中药杂志) , 2007, 32(24): 2667-2670.
[11] ZHAO M, LONG HN, HE H, et al.Gas chromatographic fingerprint of volatile oil of Valeriana officinaals[J]. Herald of Medicine(医药导报) 2016, 35(3): 291-295.
[12] YANG ZB, PENG QR, YANG M, et al.Simultaneous distillation and extraction/GC-MS methods analysis of Valeriana jatamansi volatile components[J]. Chinese Pharmaceutical Journal(中国药学杂志) , 2006, 41(1): 74-75.
[13] MING DS,YU DQ,YANG YY,et al.The structures of three novel sesquiterp enoids from Valeriana jatamansi Jones[J]. Tetrahedron Letters, 1997, 38(29): 5205-5208.
[14] LIANG GY, ZHOU X, WANG DP, et al.GC-MS study on the volatile components of Guizhou Valeriana jatamansi[J]. China Journal of Chinese Materia Medica(中国中药杂志) , 2002, 37(12): 959-959.
[15] GRANICHER F,CHERISTEN PI.Essential oils from normal and hairy roots of Valeriana officinalis var sambucifolia[J]. Phnytochemistry, 1995, 40(5): 1421-1424.
[16] LIU YH.Research on chemical constituents and bioactivities of Valeriana jatamansi and Commiphora myrrha[D]. Lanzhou: Lanzhou University, 2018.
[17] YONG Y, HUANG Q, WANG RJ, et al.Chemical constituents from Valeriana jatamansi Jones and spectral characteristics of diepoxide lignans[J]. Natural Product Research and Development(天然产物研究与开发), 2016, 28(7): 1045-1050.
[18] LIN S, FU P, SHEN YH, et al.Chemical constituents from ethyl acetate-soluble extraction of Valeriana jatamansi[J]. China Journal of Chinese Materia Medica(中国中药杂志) , 2018, 43(1): 100-108.
[19] MAO CD, SONG HZ, YANG B, et al.Chemical constituents from Rhizome of Valeriana jatamansi[J]. Journal of Chinese Medicinal Materials(中药材) , 2015, 38(8): 1665-1667.
[20] VEDANTHA M.C, MADELON J, HILDEBERT W, et al. A 13C-NMR study of the structure of an ancy-linarin from Valeriana wallichii[J]. Phytochemistry, 1977, 16(7): 1110-1112.
[21] FU L, CHU QC, HUANG BK, et al.Determination of polyphenolic constituents in Valeriana jatamansi Jones by capillary electrophoresis with electrochemical detection[J]. Chinese Journal of Analytical Chemistry(分析化学), 2005, 10(2): 161-164.
[22] LI YY, LI FT, JIN LQ, et al.TLC identification and HPLC determination of hesperidin in Valeriana Jatamansi capsule[J]. Progress in Veterinary Medicine(动物医学展), 2018, 39(12): 96-99.
[23] LI QJ, WANG QI, DU S, et al.Advances in study on the chemical constituents and antianxiety activityof Valeriana jatamansi Jones[J]. Jilin Journal of Chinese Medicine(吉林中医药), 2020, 40(9): 1254-1256.
[24] CAO B, HONG GX.Studies on central inhibition action of Valeriana jatamansi Jones[J]. China Journal of Chinese Materia Medica(中国中药杂志) , 2000, 18(5): 277-279.
[25] LI WJ, LI MY.Research progress of Valeriana officinalis[J]. Northern Horticulture(北方园艺), 2019, (12): 139-145.
[26] SONG G, WANG BH, YAN XL, et al.Purification of iridoid constituents from atamans Valeriana Rhizome by macroporous resin[J]. Journal of Beijing University of Traditional Chinese Medicine(北京中医药大学学报) , 2012, 35(3): 200-204.
[27] ZHANG RW, WU HX, LI QH, et al.Separation and identification of the components of Valeriana jatamansi[J]. Plant Diversity(云南植物研究) , 1986, 8(1): 107.
[28] XIAO D.Study on the anti-benign prostatic hyperplasia effect and mechanism of spider fragrant extract[D]. Chengdu: Journal of Chengdu University of Traditional Chinese Medicine, 2005.
[29] GHOSH S, DEBNATH. S, HAZRA. S, et al.Valeriana wallichii root extracts and fractions with activity against Leishmania spp[J] . Parasitology Research, 2011, 108(4): 861-871.
[30] KIM. J, SEO. S M, LEE S G, et al.Nematicidal activity of plant es-sential oils and components from coriander (Coriandrum sati-vum), oriental sweetgum ( Liquidambar orientalis), and valerian (Valeriana wallichii) essential oils against pine wood nematode (Bursaphelenchus xylophilus)[J]. J Agric Food Chem, 2008, 56(16): 7316.
[31] DUAN XY, FANGY, ZHOU Y, et al.General research situation of Valerian Plants[J]. China Pharmacist(中国药师), 2008, (7): 793-796.
[32] HUANG BK, ZHENG HC, QIN LP.Material basis of the sedative and hypnotic activities of Valeriana of ficinalis[J]. Pharmaceutical Care and Research(药学服务与研究) , 2006, 6(3): 165-168.
[33] CUI YJ, MU YS, YUE SJ, et al.Quantitative analysis of valtrate and acevaltrate in the Valeriana plants by TLC scanning[J]. Northwest Pharmaceutical Journal(西北药学杂志) , 1999, 14(4): 152-153.
[34] LI R, WU Y.Research progress on the pharmacological effects of Valeriana Jatamansi[J]. Science & Technology Information, 2009, 10(31): 159.
[35] ZHANG SR.Comparative study on analgesic components of valeriana jatamansi from different places[D]. Guizhou: Guizhou University, 2019.
[36] CHEN WG.Discussion on the material basis and side effects of traditional Chinese medicine taste from the chemical Components of 450 kinds of Chinese medicine[J]. China Pharmacy(中国药房), 1995, 6(2): 46-47.
[37] YU AN, TAO E, DENG QF.Studies on the organoleptic constituents of Valeriana jatamansi Jones[J]. Flavour Fragrance Cosmetics, 2002, 30(6): 14-15, 29.
[38] CHENG SY, FU Y, CHEN H, et al.Simultaneous determination of nine constituents in Valeriana Jatamansi by UPLC[J]. Chinese Traditional Patent Medicine, 2020, 42(9): 2351-2356.

彝族药蜘蛛香的研究进展及质量标志物的预测分析

Research progress in Yi medicine Valeriana jatamans and predictive analysis of related quality markers

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