中国药物警戒 ›› 2024, Vol. 21 ›› Issue (3): 355-360.
DOI: 10.19803/j.1672-8629.20220687

• 综述 • 上一篇    

硫磺熏蒸对白芷质量的影响及产地替代加工方式探讨

王常顺1,2, 王晓蕾1, 段吉平1, 袁浩1, 刘永利1,*, 赵丁2,#   

  1. 河北省药品医疗器械检验研究院,国家药品监督管理局中药材质量监测评价重点实验室,河北 石家庄,050227;
    2河北医科大学生药学教研室,河北 石家庄,050017
  • 收稿日期:2022-11-30 出版日期:2024-03-15 发布日期:2024-03-18
  • 通讯作者: *刘永利,男,硕士,主任药师,中药质量控制与质量评价研究。E-mail: Liuyongli2008@126.com。#为共同通信作者。
  • 作者简介:王常顺,女,在读博士,高级工程师,中药质量控制方法研究。
  • 基金资助:
    河北省重点研发计划项目(21372502D)

Effect of sulfur fumigation on quality of Angelica dahurica and alternative processing methods in producing areas

WANG Changshun1,2, WANG Xiaolei1, DUAN Jiping1, YUAN Hao1, LIU Yongli1,*, ZHAO Ding2,#   

  1. 1Hebei Institute for Drug and Medical Device Control, NMPA Key Laboratory for Quality Monitoring and Evaluation of Traditional Chinese Medicine (Chinese Materia Medica), Shijiazhuang Hebei 050227, China;
    2Department of Pharmacognosy, Hebei Medical University, Shijiazhuang Hebei 050017, China
  • Received:2022-11-30 Online:2024-03-15 Published:2024-03-18

摘要: 硫磺熏蒸作为一种中药材产地加工养护方法,具有治虫防霉、保持色泽光鲜、加速中药材干燥等功效。然而硫磺熏蒸也会导致中药材活性成分含量降低、转化成新的化合物,二氧化硫残留量及重金属与有害元素含量升高,导致药效降低、不良反应增加和健康风险。本文在现有文献的基础上归纳总结硫磺熏蒸对白芷质量的影响及产地加工方式探讨,为白芷的质量控制提供参考。

关键词: 硫磺熏蒸, 白芷, 活性差异, 质量控制, 产地加工, 药效, 不良反应

Abstract: Sulfur fumigation, as a processing and preservation method of traditional Chinese medicine in producing areas, is capable of insect control, mildew prevention, maintenance of bright color and acceleration of drying of traditional Chinese medicine. However, sulfur fumigation can also reduce the content of active ingredients in Chinese medicinal materials and transform them into new compounds while increasing the content of sulfur dioxide residue, heavy metals and harmful elements, which may reduce the efficacy but increase safety risks. Based on the literature available, this paper summarizes the impact of sulfur fumigation on the quality of Angelica dahurica and studies the processing methods in producing areas in order to provide reference for quality control of Angelica dahurica.

Key words: sulfur fumigation, A. dahurica, activity difference, quality control, processing in the producing area, pharmacological effect, adverse reactions

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