中国药物警戒 ›› 2023, Vol. 20 ›› Issue (8): 939-945.
DOI: 10.19803/j.1672-8629.20220409
地力乎马·地力木拉提1,2, 石伟3, 王伽伯1,*, 高源1#
收稿日期:
2022-07-31
出版日期:
2023-08-15
发布日期:
2023-08-07
通讯作者:
*王伽伯,男,博士,教授,中药药理与毒理。E-mail: jiabo_wang@ccmu.edu.cn;#为共同通信作者。
作者简介:
地力乎马·地力木拉提,女,在读硕士,中药药理与毒理。
基金资助:
DILHUMAR Dilmurat1,2, SHI Wei3, WANG Jiabo1,*, GAO Yuan1#
Received:
2022-07-31
Online:
2023-08-15
Published:
2023-08-07
摘要: 补骨脂具有温肾助阳/补肾健骨的功效,临床多用于骨质疏松、骨折、骨性关节炎等疾病的治疗。随着补骨脂的广泛使用,其不良反应报道不断增多,存在潜在安全风险,影响了补骨脂的临床用药安全。本文从古籍功效/毒性考证、临床不良反应研究、活性成分的药理作用及毒性研究、毒性机制研究、减毒控毒方法等角度对补骨脂毒/效研究进展进行分析,以期为补骨脂及其制剂的临床安全应用提供证据支持。
中图分类号:
地力乎马·地力木拉提, 石伟, 王伽伯, 高源. 基于毒/效记载演变探讨补骨脂的安全应用研究进展[J]. 中国药物警戒, 2023, 20(8): 939-945.
DILHUMAR Dilmurat, SHI Wei, WANG Jiabo, GAO Yuan. Research progress in safe use of Psoralea corylifolia based on evolution of toxicity/efficacy[J]. Chinese Journal of Pharmacovigilance, 2023, 20(8): 939-945.
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