细辛挥发油的化学成分及其药理和毒理现代研究进展

doi:10.19803/j.1672-8629.2021.04.21

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (4): 388-395.
DOI: 10.19803/j.1672-8629.2021.04.21

细辛挥发油的化学成分及其药理和毒理现代研究进展

钱深思¹, 刘美怡¹, 容蓉^1,2,3, 杨勇^1,2,3,*

¹山东中医药大学, 山东济南 250355;
²山东中医药大学实验中心,山东济南 250355;
³山东省高校中医药抗病毒协同创新中心,山东济南 250355

收稿日期:2020-09-27 出版日期:2021-04-15 发布日期:2021-04-23
通讯作者: ^*杨勇,男,博士,硕导,副教授,中药抗病毒的药效及机制研究,经方现代研究。E-mail: yy7204@163.com
作者简介:钱深思,女,在读硕士,中药药理学。
基金资助:
国家自然科学基金资助项目（81873220,81774167）

Research Progress in Chemical Constituents, Pharmacology and Toxicology of Volatile Oil in Asarum

QIAN Shensi¹, LIU Meiyi¹, RONG Rong^1,2,3, YANG Yong^1,2,3,*

¹Shandong University of Traditional Chinese Medicine, Jinan Shandong 250355, China;
²Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan Shandong 250355, China;
³Collaborative Innovation Center for Antiviral Traditional Chinese Medicine in Shandong Province, Jinan Shandong 250355, China

Received:2020-09-27 Online:2021-04-15 Published:2021-04-23

摘要/Abstract

摘要： 中药细辛的临床应用十分广泛,挥发油类物质作为其主要有效成分,具有麻醉、解热、镇痛、抗炎等药理作用,但是细辛挥发油也普遍被认为是其毒副作用的物质基础,使用不当可能会导致严重的毒性反应。通过查阅近10年文献,就细辛挥发油中主要成分及其药理和毒理作用的现代研究进行整理、分析和归纳,认为有必要对细辛挥发油中主要成分进行针对性的药效和毒性研究,以期为细辛合理和有效应用、确保临床用药安全提供参考。

关键词: 细辛, 挥发油, 化学成分, 药理作用, 毒理作用

Abstract: The clinical application of Asarum in traditional Chinese medicine is very extensive. Volatile oil, as a main active ingredient of Asarum, has a series of pharmacological effects such as anesthesia, antipyretic action, analgesia, anti-inflammation. However, Asarum volatile oil is also generally considered the material basis of its toxic and side effects, and improper use may lead to serious toxic reactions. In this study, the main components of Asarum volatile oil and recent research on their pharmacological and toxicological effects were categorized, analyzed and summarized by reviewing literature published over the past ten years. There is the need to carry out targeted pharmacodynamic and toxicological research on the main components of Asarum volatile oil in order to provide reference for the rational and effective application of Asarum and ensure the safety of clinical medication.

Key words: Asarum, volatile oil, chemical composition, pharmacological action, toxicological effects

中图分类号:

R285

钱深思, 刘美怡, 容蓉, 杨勇. 细辛挥发油的化学成分及其药理和毒理现代研究进展[J]. 中国药物警戒, 2021, 18(4): 388-395.

QIAN Shensi, LIU Meiyi, RONG Rong, YANG Yong. Research Progress in Chemical Constituents, Pharmacology and Toxicology of Volatile Oil in Asarum[J]. Chinese Journal of Pharmacovigilance, 2021, 18(4): 388-395.

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细辛挥发油的化学成分及其药理和毒理现代研究进展

Research Progress in Chemical Constituents, Pharmacology and Toxicology of Volatile Oil in Asarum

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