中国药物警戒 ›› 2020, Vol. 17 ›› Issue (3): 169-173.
DOI: 10.19803/j.1672-8629.2020.03.09

• 安全与合理用药 • 上一篇    下一篇

垂体后叶注射液致皮肤坏死文献分析

陈世伟1, 谢晓燕2, 夏旭东1, 杨雪1, 刘翠丽3   

  1. 1 河南省食品药品评价中心,河南 郑州 450018;
    2 开封市药品不良反应监测中心,河南 开封475000;
    3 国家药品监督管理局药品评价中心,北京 100045
  • 收稿日期:2020-03-17 修回日期:2020-03-17 出版日期:2020-03-15 发布日期:2020-03-17
  • 作者简介:陈世伟,男,博士,药械安全性监测与评价。

Literature Analysis of Skin Necrosis Induced by Posterior Pituitary Injection

CHEN Shiwei1, XIE Xiaoyan2, XIA Xudong1, YANG Xue1, LIU Cuili3   

  1. 1 Food and Drug Reevaluation Center of Henan Province, Zhengzhou Henan 450018, China;
    2 Kaifeng Center for ADR Monitoring, Kaifeng Henan 475000, China;
    3 Center for Drug Reevaluation, NMPA, Beijing 100045, China
  • Received:2020-03-17 Revised:2020-03-17 Online:2020-03-15 Published:2020-03-17

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摘要： 目的 探讨垂体后叶注射液致皮肤坏死的一般特点和规律。方法 以“垂体后叶注射液”“皮肤坏死”“不良反应”等为检索词,检索中国知网、万方等数据库,检索周期为建库至今,对18篇符合标准的文献进行统计分析。结果 垂体后叶注射液致皮肤坏死主要发生于41~50岁男性患者;原患疾病以肝硬化大出血为主;多发生于下肢;最集中的用量、时间范围是每天20~80U和3小时至2天。结论 重视垂体后叶注射液致皮肤坏死,加强临床用药监测,开展重点监测并完善药品说明书。

关键词: 垂体后叶注射液, 皮肤坏死, 不良反应

Abstract: Objective To investigate the common characteristics and regularity of skin necrosis induced by posterior pituitary injection. Methods With " posterior pituitary injection" "skin necrosis", and "adverse drug reaction" as the key words, such databases as CNKI, VIP and WanFang Database were searched. Eighteen articles which met the inclusion and exclusion criteria were selected. Results Skin necrosis caused by posterior pituitary injection mainly occurred in male patients aged 41 to 50, and the primary disease was massive hemorrhage of liver cirrhosis that mostly occurred in lower limbs. The dominating dosages ranged from 20 to 80u per day and skin necrosis was most likely to occur between 3 hours and 2 days. Conclusion Skin necrosis caused by posterior pituitary injection deserves more attention, so clinical drug monitoring has to be strengthened and drug instructions improved.

Key words: posterior pituitary injection, skin necrosis, adverse drug reaction

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