Abstract: ObjectiveTo explore the clinical applications and adverse reactions of lansoprazole and provide literature basis and idea for the application range and safety issues of lansoprazole. MethodsReferences in the last decades at home and abroad about the clinical pharmacological actions and adverse reactions of lansoprazole were collated, analyzed and summarized. ResultsLansoprazole is always used to treat the diseases of duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome and other digestive function disorder diseases. Compared with other proton-pump inhibitors, lansoprazole has the advantages of higher curative effect and less adverse reactions. ConclusionWe'd better be in accordance with the drug instructions or under the guidance of pharmacist when lansoprazole has to be used for the corresponding disease. The dosages and treatment course should be controlled to reduce adverse reactions. At the same time, the researches of indication, usage, dosage and treatment course of lansoprazole combined with Chinese herbs and/or western medicine should be paid more attention to improve its rationality and effectiveness.

Key words: lansoprazole, proton-pump inhibitor, digestive function disorder disease, adverse reaction