Risk Analysis and Measures of Toxic Epidermal Necrosis Caused by Allopurinol

Abstract

Abstract: By analyzing clinical symptoms and pathogenesis of toxic epidermal necrolysis induced by allopurinol, various risk factors of its toxic epidermal necrolysis were discussed including age, sex, liver and kidney dysfunction, daily dose and duration of use, drug interactions, and special populations, et al. Measures to control serious adverse reactions were proposed. It hopes to provide references for clinical safe use of allopurinol, effective prevention and control of its harm.

Key words: allopurinol, toxic epidermalnecrosis, risk management

CLC Number:

R971.1

LIANG Xiao-Dong, Zhang Li JIA, Zhi-Dan WEI, Huai-Ling ,BAO Xiu-Qi, ZHANG Dan ,SUN Hua. Risk Analysis and Measures of Toxic Epidermal Necrosis Caused by Allopurinol[J]. Chinese Journal of Pharmacovigilance, 2014, 11(8): 485-487.

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Risk Analysis and Measures of Toxic Epidermal Necrosis Caused by Allopurinol

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