Abstract: ObjectiveTo provide literature evidence and research ideas for determining the correlation of efficacious and toxic substance basis as well as the correlation of its efficacy and toxicity of Psoralea corylifolia, making safety standards, and studying its toxicity based on its efficacious substance basis. MethodsReferences in old days and last decades at home and abroad about Psoralea corylifolia were collated, analyzed and summarized. ResultsThe references in old days were lacking in the records of toxicity of Psoralea corylifolia. The recent researches were confined to the isolated aspect such as pharmacology, toxicology, chemical constituents and lacked the correlations of efficacy, toxicity and material basis. Consequently, blameless safely using standards should be made based on efficacy and material basis, and insure that its toxicity could be scientifically controlled. ConclusionOnly study Psoralea corylifolia's toxicity and control safely the toxic material basis during the expression of effectiveness and the separation and quality controlling of efficacious material basis, could we put forward early-warning scheme and treatment measures of adverse reaction in clinical usage, so as to ensure the safe use of Psoralea corylifolia as a clinical drug.

Key words: Psoralea corylifolia L., efficacy, material basis, toxicity