Abstract: Objective To offer experimental basement for the further study of dependablity between "toxicity-efficacy" by researching the adjoint toxical mechanism of anti-inflammatory effect of water and alcohol extract from Fructus Bruceae. Methods The model of ear swelling by croton oil and granuloma by agar were made and model mice were administrated with water and alcohol extract from Fructus Bruceae of high, middle and low dosage 3/7 days continually. The activities of serum SOD, GSH-Px and contents of MDA, GSH were detected after the last administration. Results Only activities of SOD and GSH-Px and content of GSH in serum of mice in high dosage group decreased significantly while the content of MDA increased after the third administration of water and alcohol extract from Fructus Bruceae. Serum activities of SOD and GSH-Px and content of GSH of all drug groups decreased significantly while the content of MDA increased after the seventh administration and showes a dependability with dosage. Conclusion Peroxidation injury is a considerable mechanism by which water and alcohol extract from Fructus Bruceae caused the adjoint toxical mechanism of anti-inflammatory effect to mice. Whether there are other mechanisms still need further study.

Key words: Fructus Bruceae, adjoint toxical and side effects, peroxidation injury