Abstract: Objective To analyze the situation of proton pump inhibitors for stress ulcer in a hospital and instruct the rational application of the drug. Methods 240 medical records of patients from 8 clinical departments including department of gastroenterology which used PPIs from January to June 2014 were randomly chosen. What used for preventing stress ulcer were sampled for the evaluation of indications in prophylactic medication, the variety of drug, usage and dosage, course of treatment. Results There were 115 copies(47.91%)which used PPIs for preventing stress ulcer, 59 copies of them(51.30%)were unreasonable. No indications and long course of treatment were the main problems. Conclusion There are still some unreasonable situations on the prophylactic use of PPIs in a hospital, the related departments should strengthen the supervision and management.

Key words: proton pump inhibitors, stress ulcer, rational drug use