Abstract: Objective To provide literature evidences asis and research ideas of efficacy and toxicity of the chemical composition of guided separation,control and efficacy, and the research on the "dose-effect relationship" and "dose-toxicity relationship” about the toxicial components. MethodsReferences in old days and in the last decades both at home and abroad about Asarum were collated,analyzed and summarized. ConclusionThe research on Asarum about the toxicity and margin of safety control based on the chemical separation and quality control about the effective material basis combined with the process of the effectiveness of expression,so as to provide consummating safety standards and putting forward early-warning scheme of adverse reaction,the early diagnosis and treatment measures that can be referred to clinical usage. Asarum will be ensured to use safety as a clinical drug.

Key words: Asarum, efficacy, material basis, toxicity