One case of extremely severe thrombocytopenia caused by niraparib tosilate capsules

doi:10.19803/j.1672-8629.20260261

Abstract

Abstract: Objective To investigate a case of extremely severe thrombocytopenia induced by niraparib tosilate capsules and to provide a reference for its safe clinical use. Methods One case of extremely severe thrombocytopenia after taking niraparib was analyzed, and the causes of thrombocytopenia and clinical management strategies were reviewed based on related literature. Results Based on a correlation evaluation, the patient’s extremely severe thrombocytopenia was believed to have been caused by niraparib. After discontinuation of the drug and symptomatic treatment, the platelet count returned to normal and bleeding symptoms were resolved. Conclusion Niraparib may cause severe thrombocytopenia during clinical use. Routine monitoring with complete blood counts is recommended during treatment. If a significant decrease in platelet count occurs or bleeding-related symptoms are observed, the drug should be discontinued immediately and appropriate treatments offered to ensure patients’ safety and prevent serious adverse reactions.

Key words: Niraparib Tosilate Capsules, Poly ADP-Ribose Polymerase Inhibitors, Thrombocytopenia, Ovarian Neoplasms, Adverse Drug Reaction

CLC Number:

R994.11

Jin Xiaoqian, He Zhijie. One case of extremely severe thrombocytopenia caused by niraparib tosilate capsules[J]. Chinese Journal of Pharmacovigilance, 2026, 23(7): 823-825.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20260261

https://zgywjj.magtechjournal.com/EN/Y2026/V23/I7/823

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