Research Progress in the Pathogenesis of Acute Lung Injury and Interventions with Traditional Chinese Medicine

doi:10.19803/j.1672-8629.20250593

Abstract

Abstract: Objective To explore the advancements in research on interventions by traditional Chinese medicine and its active ingredients in acute lung injury (ALI) so as to provide a reference for the development of novel TCM-based pharma-cotherapies and for precision clinical strategies for the prevention and treatment of ALI. Methods The pathophysiological mechanisms underlying ALI were summarized. Recent research progress in mitigating ALI via TCM and its active components by modulating key pathways, including inflammation, oxidative stress, and the gut-lung axis was analyzed. Results ALI and its more severe form, acute respiratory distress syndrome (ARDS), were leading causes of respiratory failure in critically ill patients and were associated with high morbidity and mortality. The pathogenesis of ALI was complex, involving multiple interconnected pathological processes, including dysregulated inflammation, oxidative stress, apoptosis, and disruption of the alveolar-capillary barrier. These factors were intertwined to form a sophisticated pathological network. Current clinical management of ALI primarily relied on organ support and anti-inflammatory therapies, and specific and effective interventions were lacking. Conclusion TCM, characterized by a holistic regulatory approach through multi-target and multi-pathway mechanisms, is well-aligned with this intricate pathological network and offers unique therapeutic advantages. This compatibility suggests that TCM promises to be an adjunctive approach to ALI, so more research is needed.

Key words: Acute Lung Injury(ALI), Pathogenesis, Traditional Chinese Medicine Intervention, Multi-Target, Inflammation and Oxidative Stress, Programmed Cell Death

CLC Number:

R256
R994.11

NIU Yuanfei, LIU Meiting, RONG Wenshuang, MA Lina, GU Yuanyuan, ZHANG Lichun, HOU Hongping, YANG Mengyuan, ZHENG Changhui, FU Yao, HE Ting, ZHAO Wei, WANG Lianmei, CAO Junling. Research Progress in the Pathogenesis of Acute Lung Injury and Interventions with Traditional Chinese Medicine[J]. Chinese Journal of Pharmacovigilance, 2026, 23(6): 714-719.

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https://zgywjj.magtechjournal.com/EN/Y2026/V23/I6/714

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