One Case of Drug-Induced Liver Injury Caused by Linezolid Injection

doi:10.19803/j.1672-8629.20250733

Abstract

Abstract: Objective To analyze one case of drug-induced liver injury (DILI) caused by linezolid injection, and to provide references for safe medications. Methods One case of DILI caused by linezolid combined with imipenem/cilastatin sodium for anti-infection in a patient with twin pregnancy after second-trimester induction of labor was analyzed. The causal relationship between the administered drugs and DILI was quantitatively evaluated using the Roussel Uclaf Causality Assessment Method(RUCAM) scale. Additionally, related literature was reviewed to summarize the clinical characteristics of and therapeutic strategies for such cases. Results Three days after the patient received anti-infection treatment with linezolid combined with imipenem/cilastatin sodium, liver enzymes increased significantly, with alanine aminotransferase (ALT) reaching 212.24 U·L^-1 and aspartate aminotransferase (AST) reaching 222.76 U·L^-1. According to the score by the RUCAM scale, the causality between DILI and linezolid in this patient was determined as “probable”. After linezolid was immediately discontinued and hepatoprotective therapy was initiated, liver enzymes decreased significantly. Conclusion Clinicians should be alert for the risk of DILI induced by linezolid in special physiological populations such as those during the post-pregnancy and postpartum period. Liver function indicators and related symptoms of patients should be monitored closely to detect DILI early and reduce the risk.

Key words: Linezolid Injection, Imipenem and Cilastatin Sodium for Injection, Twin Pregnancy, Drug-Induced Liver Injury, Adverse Drug Reaction

CLC Number:

TANG Liu, LI Yang, LUO Guangwen, BAO Yindi. One Case of Drug-Induced Liver Injury Caused by Linezolid Injection[J]. Chinese Journal of Pharmacovigilance, 2026, 23(5): 572-574.

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https://zgywjj.magtechjournal.com/EN/Y2026/V23/I5/572

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