Research Progress in Therapeutic Drug Monitoring Based on Liquid Chromatography-Mass Spectrometry Technology in Precision Medicine

doi:10.19803/j.1672-8629.20250383

Abstract

Abstract: Objective To summarize the research progress in therapeutic drug monitoring (TDM) based on liquid chromatography-mass spectrometry (LC-MS) technology in precision medicine so as to provide a reference for clinical precision medicine. Methods By searching China National Knowledge Infrastructure (CNKI), Chinese Medical Journal Network, Wanfang Database, and PubMed for related literature that was published between June 1, 2011 and May 31, 2025, this study summarized the applications of TDM among specific patients and described the prospects of and challenges to TDM based on LC-MS technology. Results TDM and real-time adjustment of doses of drugs could maximize efficacy of drugs and help prevent adverse drug reaction(ADR). LC-MS technology was widely used in the field of TDM due to its high sensitivity, specificity and accuracy. Conclusion TDM is a key clinical tool that can accurately evaluate the clinical efficacy and safety of drugs. TDM based on LC-MS technology can formulate individualized drug delivery schemes for patients and boost advances in clinical precision medicine.

Key words: Liquid Chromatography-Mass Spectrometry, Therapeutic Drug Monitoring, Drug Dosage, Individualized Therapy, Precision Medicine

CLC Number:

R965
R917

LIU Xue, HUANG Fujing, FAN Ling, XIE Xingxing, YU Zhigang. Research Progress in Therapeutic Drug Monitoring Based on Liquid Chromatography-Mass Spectrometry Technology in Precision Medicine[J]. Chinese Journal of Pharmacovigilance, 2026, 23(4): 476-480.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20250383

https://zgywjj.magtechjournal.com/EN/Y2026/V23/I4/476

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