Core Prescriptions for Oral Gangrene Based on “Literature Prescriptions-Medical Record Practices-Network Prediction”

doi:10.19803/j.1672-8629.20250655

Abstract

Abstract: Objective To analyze the way ancient and modern proved prescriptions for oral gangrene are used in order to provide data for clinical medication and development of new drugs. Methods Prescriptions, ancient or modern, for the treatment of gangrene were collected before drug frequency, association rules, and compatibility of combination prescriptions were analyzed using the Traditional Chinese Medicine Inheritance Platform System (TCMICS) 3.0. The pharmacodynamic effects of potential prescriptions were predicted based on the TCMATCOV platform. Results A total of 389 ancient proved prescriptions were obtained, involving 450 types of traditional Chinese medicinal materials, and 167 pairs of high-frequency drug combinations, compared with 132, 221 and 242 respectively for modern proved cases. The percentage of common drug pairs was 7% (28), such as Glycyrrhizae Radix et Rhizoma-Angelicae Sinensis Radix and Angelicae Sinensis Radix-Astragali Radix. Five types of core prescriptions were obtained from the ancient proved prescriptions and modern proved cases. The results of the TCMATCOV platform analysis showed that drug combinations of the ancient proved recipes and modern proved cases had high scores. Based on comparisons, drug combination (Olibanum, Angelicae Sinensis Radix, Myrrh, Glycyrrhizae Radix et Rhizoma, Lonicerae Japonicae Flos, Angelicae Dahuricae Radix) from ancient proved prescriptions proved to be the best target of development. Conclusion By taking gangrene as an example, the “literature prescriptions-medical record practices-network prediction” method has been established, which can provide references for the prevention and treatment of clinically dominant diseases and the screening of candidate prescriptions of traditional Chinese medicine.

Key words: Glycyrrhizae Radix et Rhizoma-Angelicae Sinensis Radix, Angelicae Sinensis Radix-Astragali Radix, Gangrene, Prescription Screening, Data Mining, Ancient Proved Prescriptions, Modern Proved Cases

CLC Number:

R282
R994.11

CHANG Mengli, ZHANG Fengrong, LI Yu, WANG Huanhuan, XU He, ZHANG Yi, WU Hongwei, TANG Shihuan. Core Prescriptions for Oral Gangrene Based on “Literature Prescriptions-Medical Record Practices-Network Prediction”[J]. Chinese Journal of Pharmacovigilance, 2026, 23(4): 443-449.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20250655

https://zgywjj.magtechjournal.com/EN/Y2026/V23/I4/443

References

[1] Diagnostic Basis, Syndrome Classification,Efficacy Evaluation for Gangrene (Tuo Ju) in the Traditional Chinese Medicine Industry Standard of the People's Republic of China-"Criteria of Diagnosis and Therapeutic Effect of Internal Diseases and Syndromes in Traditional Chinese Medicine" (ZY/T001.1-94)[J]. Journal of Liaoning University of Traditional Chinese Medicine(辽宁中医药大学学报), 2018, 20(6): 215.
[2] HAO GJ, YANG XH, BAI ZX.Analysis of Professor BAI Zhixiang's Experience in Treating Gangrene from Kidney Deficiency[J]. Tianjin Journal of Traditional Chinese Medicine(天津中医药), 2022, 39(1): 11-14.
[3] WANG J, HAO JP, ZHOU SX, et al.Clinical Experience in Treating Anthrax from the Perspective of the Spleen and Stomach[J]. Asia-Pacific Traditional Medicine(亚太传统医药), 2017, 13(22): 38-39.
[4] WANG Y, WANG ZY, WANG K, et al.Cui Gongrang's Experience in Diagnosing and Treating Gangrene Based on the Theory of “Regulating Blood and Meridians”[J]. Global Traditional Chinese Medicine(环球中医药), 2021, 14(8): 1462-1464.
[5] SONG W, AI RD, XIAO M, et al.The Experience of Ai Rudi in Diagno-sing and Treating Gangrene by Applying the“Dredging Therapy”[J]. Journal of Li-Shizhen Traditional Chinese Medicine(时珍国医国药), 2021, 32(10): 2519-2521.
[6] SUN LM.Comments and Suggestions on The Research of Preponderant Diseases of Traditional Chinese Medicine[J]. China Journal of Traditional Chinese Medicine(中华中医药杂志), 2022, 37(3): 1271-1273.
[7] The State Council of the People's Republic of China. Opinions of the CPC Central Committee and the State Council on Promoting the Inheritance, Innovation and Development of Traditional Chinese Medicine[J]. Gazette of the State Council of the People's Republic of China(中华人民共和国国务院公报), 2019(31): 6-10.
[8] TANG S, YANG H.Function and Application of Traditional Chinese Medicine Inheritance Calculate System[J]. Science of Traditional Chinese Medicine, 2024, 2(1): 66-69.
[9] ZHANG B, XI Y, HUANG Y, et al.Integration of Single-Nucleus RNA Sequencing and Network Disturbance to Elucidate Crosstalk between Multicomponent Drugs and Trigeminal Ganglia Cells in Migraine[J]. Journal of Ethnopharmacology, 2024, 319(Pt 3): 117286.
[10] Chinese Pharmaco poeia Commission. Pharmacopoeia of the People’s Republic of China(中华人民共和国药典)[M]. Beijing: China Medical Science Press, 2025.
[11] GAO XM.Science of Chinese Materia Medica(中药学)[M]. Beijing: China Press of Traditional Chinese Medicine, 2002.
[12] STELZER G, ROSEN N, PLASCHKES I, et al. The Genecards Suite: from Gene Data Mining to Disease Genome Sequence Analyses[J]. Current Protocols in Bioinformatics, 2016, 54: 1.30.1-1.30.33.
[13] XU HY, ZHANG YQ, LIU ZM, et al.ETCM: an Encyclopaedia of Traditional Chinese Medicine[J]. Nucleic Acids Research, 2019, 47(D1): 976-982.
[14] GUO FF, ZHANG YQ, TANG SH, et al.TCMATCOV-a Bioinformatics Platform to Predict Efficacy of TCM against COVID-19[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2020, 45(10): 2257-2264.
[15] CHEN SG.Wai Ke Zheng Zong(外科正宗)[M]. Beijing: China Medical Science and Technology Press, 2018.
[16] LI PL, CHEN XY, BAO XK.Research Progress of Simiao Yong’an Decoction in Treatment of Diabetic Foot Ulcer[J]. Journal of Clinical Medicine in Practice(实用临床医药杂志), 2025, 29(13): 132-136.
[17] HE QQ, YANG XH, CAO Y.The Mechanism of Buyang Huanwu Decoction Promotion of Diabetic Foot Ulcer Healing Based on Analysis of the ERK Signaling Pathway[J]. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine(浙江中西医结合杂志), 2023, 33(11): 997-1001.
[18] DUAN TM, BEN Y, ZHANG TY, et al.Effects of Buyang Huanwu Decoction on Mitochondrial Pathway Apoptosis in Retina of Diabetic Rats[J]. Chinese Journal of Clinal Pharmacology(中国临床药理学杂志), 2023, 39(17): 2527-2531.
[19] XIANG QW,LIU JJ,PENG L, et al.Effects of DangguiSini Decoction Containing Serum on Mitochondrial Division and Rhoa/ROCK Pathway of Dorsal Root Neurons of SD Rats Cultured with High Glucose[J]. Journal of Clinical Medicine in Practice(实用临床医药杂志), 2022, 26(1): 31-35.
[20] LIU AL, YU J, ZHANG SY, et al.A Case of Adverse Reactions Caused by Bufonis Venom Powder[J]. Studies of Trace Elements and Health(微量元素与健康研究), 2025, 42(1): 33-35.
[21] WU YX, MAO NY, SUN WT.Legal Regulatory Dilemma and Counter-measures for the Sustainable Utilization of Animal Traditional Chinese Medicines in China[J]. Medicine and Society(医学与社会), 2024, 37(7): 108-114.
[22] LIU SJ, WU SC, MA YL, et al.Investigation and Analysis of Mineral Chinese Medicine Species, Market Circulation and Clinical Application in China[J]. Chinese Traditional and Herbal Drugs(中草药), 2023, 54(19): 6555-6568.
[23] YANG HJ,TANG SH,SHEN D.Research Strategy on New Drug Discovery Based on Knowledge of Traditional Chinese Medicine and Clinical Practices[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2014, 20(14): 1-4.