Research Progress in Metabolomics of Depression and Regulatory Mechanisms of Traditional Chinese Medicine

doi:10.19803/j.1672-8629.20250012

Abstract

Abstract: Objective To summarize the research progress in the involvement of metabolites in the pathogenesis of depression and in treatments for depression with traditional Chinese medicine. Methods The way in which differential metabolites changed in patients with depression and the effects of traditional Chinese medicine on metabolites and pathways were explored. Results The differential metabolites in patients with depression were concentrated in such pathways as the metabolism of amino acids, energy, and lipids. Traditional Chinese medicine could combat depression by affecting metabolites and pathways. Conclusion In-depth study of the changes in metabolites and pathways in patients with depression can help explore the potential pathogenesis of depression. Traditional Chinese medicine can serve as antidepressants by bringing about changes in metabolites and pathways.

Key words: Depression, Pathogenesis, Traditional Chinese Medicine, Metabolites, Metabolomics, Amino Acid Metabolism, Energy Metabolism, Lipid Metabolism

CLC Number:

R971

WANG Xuezhen, SUN Yang, SUN Qi, ZHAO Nan, WANG Lin, YUE Jiayin, MENG Fanhao. Research Progress in Metabolomics of Depression and Regulatory Mechanisms of Traditional Chinese Medicine[J]. Chinese Journal of Pharmacovigilance, 2025, 22(9): 1061-1067.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20250012

https://zgywjj.magtechjournal.com/EN/Y2025/V22/I9/1061

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