Abstract: Objective To explore the clinical characteristics and management Methods of allergic reactions that occur during copper chelation with sodium dimercaptopropane sulfonate (DMPS) in patients with Wilson’s disease (WD). Methods The clinical data of WD patients who received DMPS treatment at the Brain Disease Center of the First Affiliated Hospital of Anhui University of Chinese Medicine between January 1, 2023 and June 30, 2024 was retrospectively analyzed. Patients with allergic reactions were identified from electronic medical records. Information on demography, drug allergy history, types and clinical manifestations of allergic reactions, and management strategies were collected. Allergic reactions were graded according to the Immediate Drug Reaction Grading Scale of the United States Drug Allergy Registry (USDAR). Results A total of 1 810 patients were included. The incidence of allergic reactions was 24.09% (436 cases), among which grade 1 accounted for 46.56%, grade 2 52.29%, and grade 3 1.15%. The clinical manifestations were primarily rash, skin itching and fever. The allergic symptoms of most of the patients were relieved 2 to 4 days after anti-allergic treatment. Conclusion The incidence of allergic reactions is relatively high in patients during copper chelation with DMPS. To improve the safety and effectiveness of this treatment regimen, it is critical to monitor the occurrence of allergic reactions in clinical practice and manage them without delay.

Key words: Sodium Dimercaptopropane Sulfate, Copper Chelation Therapy, Wilson's Disease, Allergic Reaction, Antiallergic Treatment, Desensitization Therapy, Retrospective Study