Research Progress in the Pathogenesis and Medications of Trigeminal Neuralgia

doi:10.19803/j.1672-8629.20241020

Abstract

Abstract: Objective To summarize the findings of current research related to the pathogenesis of and drugs for trigeminal neuralgia (TN) so as to provide references for in-depth studies on TN. Methods Related literature published between the inception of the databases and December 29, 2024 was retrieved from such databases as CNKI, the National Science and Technology Library and PubMed before being analyzed. Results TN was likely associated with microvascular compression of the trigeminal nerve, dysfunction of ion channels, peripheral nerve injury leading to demyelination, and reactivation of herpes simplex virus type 1 (HSV-1) infection. The first-line drugs for TN included carbamazepine and oxcarbazepine. Additionally, traditional Chinese medicine (TCM) also demonstrated promising efficacy and unique advantages in the treatment of TN. Conclusion Research findings about the pathogenesis and medications of TN have been summarized so as to provide references for the clinical treatment and research and development of related drugs.

Key words: Trigeminal Neuralgia, Pathogenesis, Compression of Trigeminal Nerve Roots, Carbamazepine, Oxcarbazepine, Traditional Chinese Medicine (TCM), Demyelination

CLC Number:

LI Shuran, XIE Rui, ZHAO Ronghua, BAO Lei, GENG Zihan, SUN Qiyue, CUI Xiaolan, GUO Shanshan, SUN Jing. Research Progress in the Pathogenesis and Medications of Trigeminal Neuralgia[J]. Chinese Journal of Pharmacovigilance, 2025, 22(5): 596-600.

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https://zgywjj.magtechjournal.com/EN/Y2025/V22/I5/596

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