Chinese Journal of Pharmacovigilance ›› 2024, Vol. 21 ›› Issue (12): 1337-1342.
DOI: 10.19803/j.1672-8629.20240660

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Clinical Characteristics of Patients with Mpox in a Department of Dermatology

LIU Jing1, YAN Huiwen1, ZHAO Xingyun1, YUAN Liufeng1, ZHAO Tianwei1, ZHANG Wei2,3,4#, LUN Wenhui1,*   

  1. 1Department of Dermatology and Venereology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China;
    2National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China;
    3National Center for Infectious Diseases (Beijing), Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China;
    4Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
  • Received:2024-08-31 Online:2024-12-15 Published:2024-12-16

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Abstract: Objective To analyze the clinical characteristics and outcomes of Mpox patients in an outpatient department of dermatology at a hospital in Beijing. Methods A retrospective analysis was conducted of the clinical manifestations of 51 Mpox patients treated between June 1, 2023 and June 15, 2024 in the Department of the Dermatology, Beijing Ditan Hospital. The clinical characteristics were summarized. Results In this study, all the 51 patients with Mpox were males ages 18 to 57, with a median age of 32 years, all of whom had a history of intercourse with men before the onset of the disease, with an incubation period of 1-30 days and a median of 7 days. The most common clinical manifestations were rashes (51/51, 100%) and fever (31/51, 60.78%). The primary rash was papules or pustules with central necrotic crusting. All patients had skin rashes, 24 of whom (24/51, 47.06%) developed rashes that were limited to the genitals and perianal area, 12 (12/51, 23.53%) started with generalized pustules, and 15 (15/51, 29.41%) had rashes that were initially localized before being generalized. 31 cases (31/51, 60.78%) had fever, which did not necessarily follow the rash. There were 32 (32/51,62.75%) HIV-positive patients, 2 (2/51, 3.92%) were in the AIDS stage (CD4+ T lymphocytes < 200 cells·μL-١), and one died. There were 25 cases (25/51, 49.02%) with positive serological tests for syphilis. As symptomatic treatment, 39 patients (39/51, 76.47%) were treated with symptomatic supportive care, including topical and oral anti-infective drugs(such as fusidic acid cream, povidone iodine solution, valaciclovir and cefprozil), 12 patients received no medication, and most of the outcomes were good except for one death. Conclusion Patients during this Mpox epidemic were mostly men who had sex with men, and the clinical manifestations were primarily pustules with central necrotic scabs. Some patients were accompanied by fever, AIDS complicated with Mpox could cause death, and most patients had a good prognosis after symptomatic treatment.

Key words: Mpox, Monkeypox Virus, Rash, Fever, Men Who Have Sex With Men, AIDS, Clinical Manifestations

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