Abstract: Objective To evaluate the clinical efficacy and side effects of intrapericardial drug in the patients with malignant pericardial effusion. Methods 46 patients with malignant pericardial effusion were treated by intraducing the intra pericardial indwelling tube and drawing out the pericardial effusion and then washing the pericardial cavity with 100ml physiological saline and instillation of 20mL physiological saline, cisplatine 40mg, interleukin-2 200 MIU and dexamethasone 5mg. The tube was removed when the pericardial fluid was less than 30mL and proved by type B ultrasonic. Hydration and antiemesis should be processed during treatment. Results 15 patients achieeved complete response, 24 achieved partial response,6 patients achieved no change and 1 patients achived progressive disease. The overal response rate was 84.78 percent. The KPS score elevated 10 to 40.The main side effects were I-II grade gastrointestinal reaction, bone marrow depression and fever. No patient died of intraducing the intra pericardial indwellingtube. Conclusion Intrapericardial drug through intraducing indwelling tube maybe a safe, effective and convenient way to control the malignant pericardial sffusion.

Key words: ultrasonic guidance, intrapericardial intubation, pericardial effusion