Abstract: Objective Applying properties and flavors theory which provides guidance for clinical patterns identification and treatment to the analysis of Psoraleae Fructus's formulations, so as to provide theoretical basis and clinical application practice for security research of Psoraleae Fructus from the perspective of properties and flavors compatibility. Methods "Psoraleae Fructus", "poguzhi", "guzi", "heihuzi", "buguzhi" were used as key words. All the prescriptions containing Psoraleae Fructus were collected from the Dictionary of Traditional Chinese Medicine Prescription. The compatibility relationship between Psoraleae Fructus and different flavor herbs were evaluated and analyzed. Combined with relevant experimental results, compatible rules were explored based on properties and flavors theory. Results The common compatibility of Psoraleae Fructus in the aspects of four properties included homoflavor compatibility on behalf of Myristicae Semen, which could enhance efficacy and reduce toxicity. The combination of warm and hot could enhance efficacy with Cinnamomi Cortex as the representative. The way of toxicity-reducing included combining cold with warm, for example, Rehmanniae Radix. The common compatibility in the aspects of five flavors included combining pungent taste with sweet taste, which could reduce toxicity and enhance efficacy, for example, Polygoni Multiflori Radix. The means of toxicity-reducing included using sour taste to constraint pungent powder, for example, Schisandra Chinensis Fructus. The common means of properties and flavors compatibility included combining pungent taste with cold, which could reduce toxicity and enhance efficacy and be manifested as Salvia Miltiorrhiza Radix. The compatibility of efficacy-enhancing included pungent taste and warm, sweet taste and warm, such as Eucommia Cortex, Jujubae Fructus. Conclusion The formulation of Psoraleae Fructus had certain rule to follow in terms of properties and flavors of TCM. The way of toxicity-reducing included combining cold with warm and using sour taste to constraint pungent powder. The compatibility of efficacy-enhancing included warm and hot, pungent taste and warm, sweet taste and warm. The combination of toxicity-reducing and efficacy-enhancing included warm and warm, pungent taste and sweet taste, pungent taste and cold.

Key words: Psoraleae Fructus, properties and flavors theory, compatibility rule, toxicity-reducing, efficacy-enhancing