Observation on Efficacy of Extract from Rabbit Skin Inflamed by Vaccinia Virus in Limb Salvage Treatment of Diabetic Foot Infection

Abstract

Abstract: Objective To observe the clinical effect of extract from rabbit skin inflamed by vaccinia virus (ERSIVV) in the limb salvage treatment of diabetic foot (DF). Methods From January 2013 to June 2015, 46 DF patients with infection who needed limb salvage treatment in our hospital were selected and divided into the observation group and the control group according to treatment program, 23 cases in each group. All of patients were graded according to the Wagner and accepted surgical treatment. Then observation group received the ERSIVV, the control group was given mecobalamin injection. The clinical efficacy and complications of the two groups were compared. Results The VAS scores of the two groups decreased after treatment, and the VAS scores 2 weeks and 3 weeks after treatment in the observation group were lower than those of the control group, the total effective rates of the pain improvement in the observation group were 82.61% and 86.96%, which were higher than those in the control group (69.57% and 73.91%) (P < 0.05). The scores of neurological symptoms and signs of the two groups decreased after treatment, and the scores in the observation group were lower than those in the control group, the difference was statistically significant (P < 0.05). After treatment, the nerve conduction velocity in the two groups all increased, and the change of the observation group was more obvious (P < 0.05). There were no obvious complication and adverse reaction in the two groups during the treatment period. Conclusion The ERSIVV can effectively improve the pain, neurologic symptoms and signs of the patients with DF infection after the limb salvage treatment, promote the recovery of nerve conduction speed, it has good clinical efficacy and safety.

Key words: diabetic foot, infection, extract from rabbit skin inflamed by vaccinia virus, surgical treatment, limb salvage, wound repair

CLC Number:

R971

WANG Jun, QIU Yang, WANG Yi-cun, DAI Si-hui, WEI Chang-hui, SHI Ning-wen. Observation on Efficacy of Extract from Rabbit Skin Inflamed by Vaccinia Virus in Limb Salvage Treatment of Diabetic Foot Infection[J]. Chinese Journal of Pharmacovigilance, 2016, 13(11): 655-659.

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