Chinese Journal of Pharmacovigilance ›› 2010, Vol. 7 ›› Issue (11): 667-669.

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The Effect of Eliminated Known Adverse Drug Reaction Database of Spontaneous Reporting System for Signal Detection

LI Hong-li1, CHENG Neng-neng2*, LI Yi2 ,DU Wen-min3   

  1. 1.Shaanxi energy technology institute, Shaanxi Xi’ an 710613, China;
    2.Department of Pharmacology, School of Pharmacy, Fudan University Shanghai, Shanghai 200032 China;
    3.Shanghai Center for Drug Adverse Reaction Monitoring, Shanghai 200040, China
  • Received:2010-08-31 Revised:2016-03-09 Online:2010-11-08 Published:2016-03-09

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Abstract: Objective To study the quantitative effect and optimized strategy of eliminate known ADR database of spontaneous reporting system for signal detection. Methods Analyze 60 996 ADR reports of 2007 ~2009 from Shanghai Center for adverse Drug Reaction Monitoring by MHRA. Results The detected single number of eliminate known ADR reports of drug of interest all other reactions of 2007 ~2009 could added 164、183、200 and detected rate was raised 48.9% compare with not eliminate known ADR. And found new important ADR signals 17、11、14 respectively. Eliminate known ADR of reactions of interest-all other drugs and eliminate all known ADR simultaneously could added number of ADR signal, but they could made important signals lost. Such as acanthopanax injection bring about liver damage have not been reported up to now in other literatures. Conclusion The strategy of eliminate known ADR database of drug of interest all other reactions can improve the efficiency of ADR signal detection and it is easy to operate.

Key words: spontaneous reporting system, date mining, MHRA, signal detection

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