Abstract: Objective To discuss the role of blood concentration monitoring of sodidum valproate in preventing postoperative seizure. Methods 248 cases of sodium valproate blood concentration of brain tumor patients were retrospective analyzed in 2012, and the prophylaxis effect of epilepsy was assessed through the analysis of postoperative epilepspy in hospital. Results Normal treatment concentration was found in 160 cases(64.5%), 18 cases(7.3%) were higher than normal treatment concentration, and 70 cases(28.2% ) below the normal treatment concentration. Conclusion The blood concentration of sodium valproate was influenced by many factors. According to patients' basic situation and blood concentration monitoring, the individualized medication should be made so as to Keep an effective therapeutic concentration of sodium valproate to prevent seizares during the perioperative period.

Key words: sodium valproate, perioperative period, prophylaxis, blood concentration, individualized medication