Abstract: Objective To investigate the clinical effects of comprehensive intervention measures on rational preventive utilization of antibiotics for type I surgical incision after a special improving campaigns. Methods Medical records of type I surgical incisions from 2010 to 2013 in our hospital were randomly selected. A before and after comparison was performed on the data including utilization rate of antibiotics on type I incision, drug selection, drug combination, drug administration time before surgery and duration time after surgery. Results After the sustained intervention, rational preventive utilization of antibiotics for type I surgical incision was improved significantly. Antimicrobial utilization rate and combination utilization decreased from 100% and 34.44% before the intervention to 49.44% and 2.25% respectively. The irrational rate of drug administration time before operation and duration time after operation decreased from 32.22% and 85% to 2.22 % respectively. The selection spectrum of main antibiotics diverted from β-lactam containing enzyme inhibitors and third-generation cephalosporins before intervention to second-generation cephalosporins after intervention. Conclusion The utilization of preventive antibiotics for type I surgical incision in our hospital is rationalized, and the intervention measures are effective and feasible. But the preventive utilization rate is still high. The further measures on the supervision should be adopted to promote the rational utilization of perioperative antimicrobial drugs.

Key words: typeⅠincision operation, antibacterial agents, intervention