Abstract: Objective To study the genetic toxicity of Asarum heterotropoides Fr.Schmidt. Methods Observation whether the Decoction of Asarum heterotropoides Fr.Schmidt.Var. mandshuricum Kitag. will induce genetic material injury in male mice' somatic and germ cells or not by mouse polychromatic erythrocytes micronucleus test and mouse sperm abnormality test, indicated the genetic toxicity of Asarum heterotropoides Fr.Schmidt. by micronucleus rate and the malformation rate and deformity constituent ratio. Results Asarum heterotropoides Fr.Schmidt. could significantly induce mouse polychromatic ery-throcytes micronuclei and sperm abnormalities, it has mutagenic effect. Conclusion Asarum heterotropoides Fr.Schmidt. as a clinical efficacy of commonly used Chinese herbal medicine has a variety of genetic toxicity, clinical applications need to consider their genetic toxicity.

Key words: Asarum heterotropoides Fr.Schmidt, cyclophosphamide, sperm abnormality, micronuclei