Abstract: Objective To srudy the toxicity and side effects accompanied with anti-inflammation of water extraction components of Sophorae tonkinensis Radix et Rhizoma on throat excess-heat syndrome model in mice, provide experimental basis of "efficacy-syndrome-toxicity" relevancy. Methods The method of throat excess-heat syndrome model in mice was built, which were administrated with different doses water extraction components of Sophorae tonkinensis Radix et Rhizoma, observing anti-inflammation and toxicity by the croton oil inducing ear swelling method. detecting the level of ALT, AST, BUN, Cr in serum and calculating the ratio of liver and kidney to body, to evaluate its efficacy with side effects. Results Water extraction components of Sophorae tonkinensis Radix et Rhizoma had strong inhibitory effect on the croton oil inducing ear swelling in throat excess-heat syndrome mice after multiple administration. ALT and AST levels in serum were obviously enhanced after 3 d administration, liver weight/body ratio enhanced. Conclusion The effective dose of water extraction components of Sophorae tonkinensis Radix et Rhizoma had obvious anti-inflammatory effect, and at the same time, accompanied by side effects and hepatotoxicity. Compared with normal animals, anti-inflammatory effect is stronger and hepatotoxicity is weaker, whose toxicity mechanism still needs further research under the background of syndrome.

Key words: Sophorae tonkinensis Radix et Rhizoma, throat excess-heat syndrome, anti-inflammation, accompanied toxicity and side effects