Abstract: Objective To examine the repeated dose toxicity of Antexiao capsule in Beagle dogs. Methods 48 Beagle dogs were divided into four groups: 120, 320, 800 mg·kg-1 dose of Antexiao capsule groups and solvent control group. The dogs were orally treated with Antexiao capsule for 39 weeks. Clinical observation, body weight, electrocardiogram, hematology, blood biochemistry, organ weights, and histopathological findings were examined. Results Antexiao capsule could induce vomiting, salivation and liquid stools in healthy dogs. The body weight of dogs in 800 mg·kg-1 group decreased significantly (P <0.05). The levels of serum TP, ALB and GLOB changed in dogs treated with 320 and 800 mg·kg-1 Antexiao capsule. No significant drug-related pathological changes were found. Conclusion Antexiao capsule (320 and 800 mg·kg-1) administered intragastrically can induce significant gastrointestinal toxicity in Beagle dogs.

Key words: Antexiao capsule, total steroidal alkaloids from Solanum lyratum, Beagle dogs, repeated dose toxicity