Progress of Hypomethylating Agents in Treatment of Myelodysplastic Syndrome

Abstract

Abstract: Myelodysplastic syndrome (MDS) is a group of heterogeneous myeloid clonal diseases originated from hematopoietic stem cells and has a high risk to transform into acute myeloid leukemia. The natural course and prognosis of MDS patients are highly heterogeneous, and individualized treatment plans must be developed according to the stratification of patients' prognosis. Currently, hypomethylating agents are one of the main treatments for high-risk MDS patients. This paper summarizes the research progress of representative hypomethylating agents in recent years, and hopes to provide references for the clinical application and research of these drugs.

Key words: myelodysplastic syndrome, high risk, hypomethylating agents

CLC Number:

R965

CHANG Bingqing, SUN Wanling. Progress of Hypomethylating Agents in Treatment of Myelodysplastic Syndrome[J]. Chinese Journal of Pharmacovigilance, 2018, 15(9): 560-563.

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