Chinese Journal of Pharmacovigilance ›› 2017, Vol. 14 ›› Issue (3): 137-141.

• Orginal Article • Previous Articles     Next Articles

Pharmacodynamics Research of Yanhouning Oral Liquid Treatment on Acute or Chronic Pharygitis

SUN Jing1, GUO Shan-shan1, ZHAO Rong-hua1, LU Sai-wei2, GAO Ying-jie1, SHI Yu-jing1, CUI Xiao-lan*   

  1. 1 Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;
    2 Suzhou Youseen New Drug R&D Co.Ltd, Jiangsu Suzhou 215001, China;
  • Received:2017-04-20 Revised:2017-04-20 Online:2017-03-20 Published:2017-04-20

Abstract: Objective To evaluate the pharmacodynamic effects of Yanhouning oral liquid (YHNOL) on acute or chronic pharygitis. Methods The protective effect against acute pharyngitis was observed by spraying with 15% ammonia and injecting of beta hemolytic streptococcus at pharyngeal mucosa of rat. The protective effect against chronic pharyngitis was observed by spraying with 2.5% ammonia and injecting of turpentine into pharyngeal mucosa of rabbit. The anti-inflammatory effect was observed by the capillary permeability augmentation of mice induced by acetic acid and cotton pellet granuloma of rats. The analgesic effect was investigated by body twist method. Results Three dose of YHNOL could significantly relieve pharyngeal lesions of rats and rabbits. YHNOL could also significantly inhibit capillary permeability augmentation caused by acetic acid in mice, lighten the dry weight of granuloma induced by cotton ball in rat, depress the torsion body of mice. Conclusion YHNOL could effectively alleviate the symptoms of acute or chronic pharyngitis. It also has significant effect of anti-inflammation and abirritation.

Key words: Yanhouning oral liquid, acute pharyngitis, chronic pharyngitis, anti-inflammatory effect, analgesic effect

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