Chinese Journal of Pharmacovigilance ›› 2016, Vol. 13 ›› Issue (8): 464-467.

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Establishment of Rapid Quantitative Analysis of Water in Salvia Miltiorrhiza by Near Infrared Diffuse Reflectance Spectroscopy

HAO Lei1, LI Jun-shan1, 2, PENG Xin-hua1, WANG Xiao-kang1, GAO Hui-qin1, JIANG Guo-zhi1, LI Zhen-jiang1   

  1. 1 Shineway Pharmaceutical Group Ltd, Hebei Shijiazhuang 051430, China;
    2 Hebei Province Engineering and Technology Research Center for Traditional Chinese Medicine Formula Particles Dispensing Granule, Hebei Shijiazhuang 050090, China
  • Received:2016-09-14 Revised:2016-09-14 Online:2016-08-20 Published:2016-09-14

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Abstract: Objective To establish a quantitative model to determine the water in Salvia miltiorrhiza quickly by using near-infrared diffuse reflection technology and chemometrics method. Methods Near infrared spectra of the samples were measured by the integrating sphere. The partial least squares (PLS) calibration model was built with the first derivative spectra. Results The optimal number of the latent variables for the model was 6. The coefficient of determination (R2) for the model was 0.996 4. The root mean square error of cross-validation (RMSECV) was 0.442 and root mean square error of prediction (RMSEP) was 0.229. The relative standard deviation of the system and the method was 1.1% and 1.8% separately. Conclusion The NIRS model was proved to be a rapid and exact method for the quantitative determination of the water in Salvia miltiorrhiza.

Key words: near infrared, Salvia miltiorrhiza, moisture determination

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