Abstract: Objective To analyze the effect of renal function and combined use of drugs on serum digoxin concentration, so as to provide reference for clinical rational drug use. Methods 482 patients were subjects for study, who had been treated with digoxin in the department of cardiology of our hospital during January 2013 to January 2016, a retrospective analysis about the clinical data of all patients was carried out. All patients were divided into renal function injury group and normal renal function group according to the glomerular filtration rate. The blood drug concentrations of digoxin in different groups were compared, at the same time, the drug combination of the patients with different serum concentrations of digoxin were compared, in order to investigate the influence of renal function and drug combination on the concentrations of digoxin. Results The concentration of digaoxin in renal function injury group was higher than the normal renal function group, and the difference was statistically significant (P < 0.05). The results of spearman correlation analysis showed that, the GFR had significantly negative correlation with serum digoxin concentration (r=-0.833, P < 0.05). GFR < 60 mL·min^-1·1.73 m^-2, age≥60 years, taking beta blockers, taking thiazide diuretics, and the use of antimicrobial drugs were the risk factors affecting the serum digoxin concentration, but the use of anticoagulants was a protective factor of digoxin concentration, and had statistically significance (P < 0.05). Conclusion Serum concentration of digoxin is significantly influenced by renal function and drug combination, considering the patient’s renal function and drug combination to optimize the treatment program is very necessary.

Key words: digoxin, blood drug concentration, renal function, drug combination