Abstract: Objective To compare the protective effects of Guanxindanshen formula(GDF) different components with effectiveness by ligating coronary left descending artery with acute myocardial ischemia in rats. Methods The rat model of acute myocardial ischemia was established by ligating coronary left descending artery into sublingual vein. The incidence rates of VT and VF in rats after ligating coronary left descending artery were observed. Myocardial infarction size (MIS) of model rats was calculated and pathological examination of myocardial tissue was performed. Meanwhile, the levels of lactate dehyd rogenase (LDH), superoxide dismutase (SOD), malondialdehyde (MDA) in serum were determined by assay. Results Compared with model group, the GDF group significantly reduced infarct size, decreased the levels of LDH and MDA in serum, and increased the activities of SOD. In addition, MIS was reduced and myocardial cells were protected. The GDF group was the best to protect myocardial ischemia. Conclusion GDF different components with effectiveness can significantly inhibit acute myocardial ischemia in rats caused by ligating coronary left descending artery.

Key words: Guanxindanshen formula, coronary left descending artery, acute myocardial ischemia, protective effect