Abstract: Objective To explore the preventive effect of ondansetron,droperidol,dexamethasone and combination of the latter two administered for postoperative nausea and vomiting from continous sulfentany analgesia in cesarean patients. Methods A total of 150 women scheduled for elective cesarean section under combined spinal-epidural anesthesia were randomly divided into five groups with 30 cases each. 10 mg dexamethasone was intravenously injected in group A while operation ended. 2.5 mg droperidol was added into sulfentany PCIA pump in group B. 4 mg ondansetron was added into sulfentany PCIA pump in group C. 1.25 mg droperidol was added into sulfentany PCIA pump plus dexamethasone 5 mg intravenous injection when operation ended in group D. Group E received 4 mL of normal saline when operation ended. All patients received postoperative pain control with sulfentany intravenous PCA. The nausea and vomiting and visal analogue pain scale at 1,6,12 and 24 h after operation were recorded. Results No significant difference was observed in the pain scales among the five groups.The assessment of nausea and vomiting showed that scoring in group E was higher than groups A,B,C and D (P <0.01), and in the groups A,B and C those were higher than the group D (P<0.05), while no difference among the groups A,B and C. Conclusion Ondansetron, droperidol and dexamethasone can prevent the incidence of nausea and vomiting during sulfentany analgesia,and it would be better when they were given by combining less droperidol into the PCIA pump of sulfentany and dexamethasone intravenous injection. Not only the amount of them is used less,but also complication is avoided and less expense is needed.

Key words: ondansetron, droperidol combined with dexamethasone, sulfentany, postoperative nausea and vomiting, postoperative analgesia