Abstract: ObjectiveTo explore the dose range of anti-inflammatory effect of Tripterygium wilfordii tablets (TWT) and Tripterygium wilfordii polyglycoside (TWP)tablets and compare with the results of them, so as to provide the basis for clinical medication. MethodsMice were respectively given the different doses of TWT and TWP for 3 consecutive days by gavage. The anti-inflammatory effects of TWT and TWP were explored according to the model of ear edema by mixture of compound croton oil we made. ED50 and ED95 of anti-inflammatory efficacy and LD50 and LD5 of acute toxicity test were calculated. ResultsED50 and 95% confidence limit of TWT and TWP were respectively 17.753 (13.567~21.448) μg·kg-1, 9.236 (5.570~ 11.915) mg·kg-1, which were equal to triptolide of 17.753 μg·kg-1, 8.922 μg·kg-1. They were respectively equal to 20.30 and 10.21 times of 70 kg person's daily dried medicine expenses. ConclusionTWT and TWP show good suppression on the acute inflammation caused by mixture of compound croton oil. The potency of TWP is better than that of TWT. Triptolide with good effect of anti-inflammation shows a good "dose-effect" relationship. But it is not the only material basis of Tripterygium wilfordii for anti-inflammatory effect. The effective dose ranges of them show a certain dose-effect relationship. The mechanism of anti-inflammatory effect needs a further study.

Key words: Tripterygium wilfordii tablets, Tripterygium wilfordii polyglycoside tablets, triptolide, anti-inflammatory effect