Abstract: ObjectiveTo evaluate the dynamic accumulation changes of ursolic acid content in the cornel of different growth period and different origin, and provide the basis for the quality evaluation of medicinal materials. MethodsThe RP-HPLC method was used to determine the content of ursolic acid in different origin and different growth period of dogwood. ResultsThe content of ursolic acid in cornel showed regular change, when the total content of ursolic acid was higher. As the dogwood fruit matured, the content of ursolic acid decreased gradually, the content of ursolic acid was lowest during fruit ripening. ConclusionThe dynamic accumulation research on ursolic acid content of dogwood in different regions and different growth phase provided the certain basis for quality evaluation of cornel medicinal materials.

Key words: fructus corni, ursolic acid, dynamic accumulation